Correlation between traditional Chinese medicine syndrome type and serum Endocan in diarrheal irritable bowel syndrome
Objective It is to investigate the characteristics of syndrome differentiation and classification of irritable bowel syndrome with diarrhea(IBS-D)in traditional Chinese medicine(TCM),and to analyze its correlation with serum Endocan.Methods A total of 127 IBS-D patients treated in outpatient clinic of the Department of Splenology and Gastroen-terology of the Third Affiliated Hospital of Beijing University of Chinese Medicine from March 2022 to April 2023 were se-lected as IBS-D group,27 healthy physical examination subjects were selected as the control group.The age,gender,four diagnostic data of Chinese medicine and the results of laboratory examination and imaging examination of the subjects were collected,the distribution of TCM syndrome of IBS-D patients was counted,the serum level of Endocan of IBS-D patients with different TCM syndrome were compared,and the correlation between TCM syndrome and serum level of Endocan was analyzed by Pearson correlation analysis.Results In 127 cases of IBS-D patients,large intestine dampness-heat syndrome[29.9%(38/127)],liver depression and spleen deficiency syndrome[28.3%(36/127)]were more common,followed by cold-heat complex syndrome,spleen deficiency with dampness exuberance syndrome and spleen-kidney Yang deficiency syndrome.The serum levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and Endocan of the IBS-D group were significantly higher than those of the healthy group(all P<0.05).The differences in the serum level of En-docan among different syndrome types of IBS-D were statistically significant(all P<0.05),and the serum levels of En-docan from high to low were as follows:large intestine dampness-heat syndrome(6.31±0.48)ng/mL,liver depression and spleen deficiency syndrome(5.04±0.57)ng/mL,spleen deficiency with dampness exuberance syndrome(3.11±0.42)ng/mL,cold-heat complex syndrome(2.96±0.38)ng/mL,and spleen-kidney Yang deficiency syndrome(2.92±0.35)ng/mL.The serum level of Endocan in patients with large intestine dampness-heat syndrome was significantly higher that that of patients with other syndromes(all P<0.05),and the level in patients with liver depression and spleen defi-ciency syndrome was higher than that in patients with cold-heat complex syndrome,spleen-kidney Yang deficiency syn-drome and spleen deficiency with dampness exuberance syndrome(all P<0.05),there was no statistical significance a-mong the patients with cold-heat complex syndrome,spleen-kidney Yang deficiency syndrome and spleen deficiency with dampness exuberance syndrome(all P>0.05).Pearson correlation analysis showed that large intestine dampness-heat syndrome and liver depression and spleen deficiency syndrome were positive related with serum Endocan(both P<0.05).Conclusion There is a mild inflammatory response in IBS-D patients,and the serum level of Endocan can be used as a ref-erence index for TCM differentiation and classification of IBS-D.
irritable bowel syndrome with diarrheaEndocanlarge intestine dampness-heat syndromeliver depres-sion and spleen deficiency syndrome
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