现代中西医结合杂志2024，Vol.33Issue(7) ：895-899,905.DOI:10.3969/j.issn.1008-8849.2024.07.004

腹泻型肠易激综合征中医证型与血清Endocan的相关性研究

Correlation between traditional Chinese medicine syndrome type and serum Endocan in diarrheal irritable bowel syndrome

张洪薇 王再见 谢春娥 雷雪 李彤 高玉璇 邹茂琳 王悦卿 李会霞
现代中西医结合杂志2024，Vol.33Issue(7) ：895-899,905.DOI:10.3969/j.issn.1008-8849.2024.07.004
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腹泻型肠易激综合征中医证型与血清Endocan的相关性研究

Correlation between traditional Chinese medicine syndrome type and serum Endocan in diarrheal irritable bowel syndrome

张洪薇 1王再见 2谢春娥 3雷雪 4李彤 1高玉璇 1邹茂琳 1王悦卿 1李会霞2
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作者信息

  • 1. 北京中医药大学,北京 100020
  • 2. 北京中医药大学第三附属医院,北京 100029
  • 3. 北京中医药大学东方医院,北京 100078
  • 4. 北京市怀柔区中医医院,北京 101499
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摘要

目的 探讨腹泻型肠易激综合征(IBS-D)患者的中医辨证分型特点及其与血清内皮细胞特异性分子-1(Endocan)水平的相关性.方法 选取2022 年3 月—2023 年4 月在北京中医药大学第三附属医院脾胃病科门诊就诊的127 例IBS-D患者作为IBS-D组,另以同期27 例健康体检者作为健康组,收集受检者的年龄、性别、中医四诊辨证资料及实验室检查、影像学检查结果,统计IBS-D患者中医证型分布情况,比较不同中医证型IBS-D患者的血清Endocan水平,Pearson相关性分析中医证型与血清Endocan水平的相关性.结果 127 例IBS-D患者中,以大肠湿热证[29.9%(38/127)]、肝郁脾虚证[28.3%(36/127)]多见,其次为寒热错杂、脾虚湿盛证和脾肾阳虚证.IBS-D组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、Endocan水平均明显高于健康组(P均<0.05).IBS-D不同证型间血清Endocan水平比较差异有统计学意义(P<0.05),血清Endocan水平由高到低依次为大肠湿热证(6.31±0.48)ng/mL、肝郁脾虚证(5.04±0.57)ng/mL、脾虚湿盛证(3.11±0.42)ng/mL、寒热错杂证(2.96±0.38)ng/mL、脾肾阳虚证(2.92±0.35)ng/mL,其中大肠湿热证患者血清Endocan水平均明显高于其他证型患者(P均<0.05),肝郁脾虚证患者血清Endocan水平均明显高于寒热错杂证、脾肾阳虚证和脾虚湿盛证患者(P均<0.05),寒热错杂证、脾肾阳虚证和脾虚湿盛证患者间血清Endocan水平比较差异均无统计学意义(P均>0.05).Pearson相关性分析显示,大肠湿热证、肝郁脾虚证与血清Endocan水平均呈正相关(P均<0.05).结论 IBS-D患者机体存在轻度炎症反应,血清Endocan水平可作为IBS-D的中医辨证分型参考指标.

Abstract

Objective It is to investigate the characteristics of syndrome differentiation and classification of irritable bowel syndrome with diarrhea(IBS-D)in traditional Chinese medicine(TCM),and to analyze its correlation with serum Endocan.Methods A total of 127 IBS-D patients treated in outpatient clinic of the Department of Splenology and Gastroen-terology of the Third Affiliated Hospital of Beijing University of Chinese Medicine from March 2022 to April 2023 were se-lected as IBS-D group,27 healthy physical examination subjects were selected as the control group.The age,gender,four diagnostic data of Chinese medicine and the results of laboratory examination and imaging examination of the subjects were collected,the distribution of TCM syndrome of IBS-D patients was counted,the serum level of Endocan of IBS-D patients with different TCM syndrome were compared,and the correlation between TCM syndrome and serum level of Endocan was analyzed by Pearson correlation analysis.Results In 127 cases of IBS-D patients,large intestine dampness-heat syndrome[29.9%(38/127)],liver depression and spleen deficiency syndrome[28.3%(36/127)]were more common,followed by cold-heat complex syndrome,spleen deficiency with dampness exuberance syndrome and spleen-kidney Yang deficiency syndrome.The serum levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and Endocan of the IBS-D group were significantly higher than those of the healthy group(all P<0.05).The differences in the serum level of En-docan among different syndrome types of IBS-D were statistically significant(all P<0.05),and the serum levels of En-docan from high to low were as follows:large intestine dampness-heat syndrome(6.31±0.48)ng/mL,liver depression and spleen deficiency syndrome(5.04±0.57)ng/mL,spleen deficiency with dampness exuberance syndrome(3.11±0.42)ng/mL,cold-heat complex syndrome(2.96±0.38)ng/mL,and spleen-kidney Yang deficiency syndrome(2.92±0.35)ng/mL.The serum level of Endocan in patients with large intestine dampness-heat syndrome was significantly higher that that of patients with other syndromes(all P<0.05),and the level in patients with liver depression and spleen defi-ciency syndrome was higher than that in patients with cold-heat complex syndrome,spleen-kidney Yang deficiency syn-drome and spleen deficiency with dampness exuberance syndrome(all P<0.05),there was no statistical significance a-mong the patients with cold-heat complex syndrome,spleen-kidney Yang deficiency syndrome and spleen deficiency with dampness exuberance syndrome(all P>0.05).Pearson correlation analysis showed that large intestine dampness-heat syndrome and liver depression and spleen deficiency syndrome were positive related with serum Endocan(both P<0.05).Conclusion There is a mild inflammatory response in IBS-D patients,and the serum level of Endocan can be used as a ref-erence index for TCM differentiation and classification of IBS-D.

关键词

腹泻型肠易激综合征/内皮细胞特异性分子-1/大肠湿热证/肝郁脾虚证

Key words

irritable bowel syndrome with diarrhea/Endocan/large intestine dampness-heat syndrome/liver depres-sion and spleen deficiency syndrome

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基金项目

首都卫生发展科研专项(首发2022-1-4201)

出版年

2024
现代中西医结合杂志
中国中西医结合学会河北分会,中华中医药学会

现代中西医结合杂志

CSTPCD
影响因子：1.775
ISSN：1008-8849
参考文献量26
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