Efficacy of five element tonality to regulating spirit on post stroke fatigue of syndrome of liver depression and spleen deficiency
Objective It is to explore the efficacy of five element tonality to regulating spirit and its mechanism in the treatment of patients with post stroke fatigue(PSF)of syndrome of liver depression and spleen deficiency.Methods Seven-ty-four patients with PSF of syndrome of liver depression and spleen deficiency diagnosed and treated in the Department of Rehabilitation Medicine of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from June 2022 to June 2023 were selected,and were divided into group of five element tonality to regulating spirit and conventional treatment group by randomized numerical table,with 37 cases in each group,1 case in each group dropped,and 72 cases finally completed the study.The conventional treatment group was treated with conventional internal medicine basic therapy and conventional rehabilitation training,and the group of five element tonality to regulating spirit was treated with group five element tonality to regulating spirit on the basis of the conventional treatment group.The scores of Fatigue Severity Scale(FSS),Hamilton Depression Scale 17-item version(HAMD-17),Hamilton Anxiety Scale(HAMA),Pittsburgh Sleep Quality Index(PSQI),Stroke Specialized Quality of Life(SS-QOL),and serum level of 5-HT of patients in the two groups were compared before and after the treatment,the correlations of the HAMD-17 score,HAMA score,PSQI score,and PS-QOL score with FSS score were analyzed.Results The HAMD-17 scores,HAMA scores,PSQI scores of the two groups and FSS score of the group of five element tonality to regulating spirit were significantly decreased after treatment compared with before treatment(all P<0.05),while the SS-QOL scores of the two groups and serum level of 5-HT of the group of five el-ement tonality to regulating spirit were significantly increased(all P<0.05).After treatment,the FSS score,HAMD-17 score,HAMA score,and PSQI score of the group of five element tonality to regulating spirit were significantly lower than those of the conventional treatment group(all P<0.05),and the SS-QOL score and serum 5-HT level were significantly higher than those of the conventional treatment group(all P<0.05).The HAMD-17 score,HAMA score,and PSQI score were positively correlated with FSS score(r=0.644,P<0.001;r=0.691,P<0.001;r=0.632,P<0.001).Conclu-sion The treatment with five element tonality to regulating spirit can effectively reduce fatigue,improve anxiety,depression and insomnia,and improve the quality of life of patients with l post stroke fatigue of syndrome of liver depression and spleen deficiency,and the mechanism may be related to up-regulating the level of 5-HT.
strokepost stroke fatiguesyndrome of liver depression and spleen deficiencyfive elementsmusic therapyacupuncture
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