Therapeutic efficacy of granules for moving Qi and dispersing goiter on thyroid nodules of syndrome of Qi stagnation and phlegm obstruction
Objective It is to observe the clinical efficacy of granules for moving Qi and dispersing goiter in the treat-ment of thyroid nodules of syndrome of Qi stagnation and phlegm obstruction.Methods Seventy-seven patients with thyroid nodules of syndrome of Qi stagnation and phlegm obstruction diagnosed and treated in Shaanxi Provincial Hospital of Tradi-tional Chinese Medicine from April to December 2022 were selected as the study subjects,and were randomly divided into 2 groups:39 patients in the treatment group were given granules for moving Qi and dispersing goiter orally,and 38 patients in the control group were given Prunella oral liquid orally,both groups were treated for 3 months.The changes of scores of Chinese medicine syndromes,maximum diameter of thyroid nodules and indexes of thyroid function(including antibody)of patients in the two groups were observed,the efficacy of Chinese medicine syndrome and nodule treatment in the two groups were compared,and the occurrence of adverse reactions in the two groups was recorded.Results The scores of Chinese medicine syndromes and the maximum diameter of thyroid nodules of patients in the two groups were significantly reduced after treatment,and the improvements were more significantly in the treatment group than those in the control group,the differences were all statistically significant(all P<0.05).The differences in the levels of free triiodothyronine(FT3),free thyroxine(FT4),and thyrotropin(TSH)before and after the treatment were not statistically significant in the two groups(all P>0.05).The levels of antithyroid peroxidase antibody(TPOAb)and antithyroglobulin antibody(TGAb)were significantly lower after treatment than those before treatment in the patients of two groups with abnormal thyroid anti-bodies,and the level of TPOAb in the treatment group was significantly lower than that in the control group after treatment,the differences were all statistically significant(all P<0.05).The total effective rate of Chinese medicine syndrome was 55.3%(21/38),and the total effective rate of nodule treatment was 47.4%(18/38)in the control group,and those in the treatment group were76.9%(30/39)and74.4%(29/39),respectively,the rats of the treatment group were signifi-cantly higher than those of the control group(both P<0.05).There were no adverse reactions in the two groups.Conclu-sion Granules for moving Qi and dispersing goiter is effective in the treatment of thyroid nodules of syndrome of Qi stagna-tion and phlegm obstruction,and it can reduce the levels of TPOAb and TGAb with good safet.
thyroid nodulesgranules for moving Qi and dispersing goitersyndrome of Qi stagnation and phlegm ob-struction
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