Efficacy of Qi Ju Dihuang Pills combined with Stullen on myopic atrophic maculopathy of liver and kidney deficiency type
Objective It is to observe the clinical efficacy of Chinese patent medicine for tonifying and replenishing liv-er and kidney Qi Ju Dihuang Pills combined with Stullen in the treatment of patients with myopic atrophic maculopathy(MAM)of liver and kidney deficiency type.Methods Sixty patients with MAM of liver and kidney deficiency type treated in the outpatient clinic of Fundus Surgery Department of Affiliated Eye Hospital of Shandong University of Traditional Chi-nese Medicine from January 2021 to December 2022 were selected as the study subjects,and were divided into control group and treatment group by random number table method,with 30 cases(30 eyes)in each group.The control group was given Stullen to the affected eyes by eye drop,and the treatment group was orally administered with Qi Ju Dihuang Pills on the basis of treatment with Stullen,both groups were treated for 30 days.The scores of traditional Chinese medicine syn-drome and related ocular parameters[(uncorrected and best corrected visual acuity,spherical equivalent,light sensitivity,mean defect,central macular thickness(CMT),subfoveal choroidal thickness(SFCT)]of patients in the two groups be-fore and after the treatment were compared,and the related ocular parameters of patients with different classifications of my-opic maculopathy degeneration(MMD)[diffuse chorioretinal atrophy(C2),patchy chorioretinal atrophy(C3),macular atrophy(C4)]in the two groups were compared.Results After treatment,the scores of traditional Chinese medicine syn-drome of the two groups were significantly lower than those before treatment(both P＜0.05),and the treatment group was significantly lower than the control group(P＜0.05).After treatment,the difference in uncorrected and best corrected vis-ual acuity between before and after treatment in each group and between the two groups were not statistically significant(all P＞0.05),but the uncorrected and best corrected visual acuity of patients of C2 in the treatment group were significantly higher than those before treatment and in the control group(all P＜0.05);the total light sensitivity of the treatment group was significantly higher than that before treatment and in the control group(both P＜0.05),the light sensitivities of pa-tients of C2 and C3(efficacy of C2 was the best)in the treatment group were significantly higher than those before treat-ment and of the same classification in control group(all P＜0.05);the differences in spherical equivalent,CMT and SF-CT were not statistically significant between before and after treatment in each group and between the two groups(all P＞0.05),and the differences were not statistically significant among patients of different classifications(all P＞0.05).Con-clusion Efficacy of Qi Ju Dihuang Pills combined with Stullen is good in the treatment of myopic atrophic maculopathy of liver and kidney deficiency type,which can effectively improve patients'traditional Chinese medicine syndrome and light sensitivity,and effectively improve uncorrected and best corrected visual acuity of patients at early stage(class C2).
myopic atrophic maculopathyQi Ju Dihuang PillsStullentraditional Chinese medicine syndromelight sensitivitybest corrected visual acuity
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