Therapeutic efficacy of decoction for fortifying spleen,warming kidney and activating blood on diabetic kidney disease and its effects on renal function and serum inflammatory factors
Objective It is to explore the efficacy of decoction for fortifying spleen,warming kidney and activating blood combined with irbesartan in the treatment of diabetic kidney disease and its effects on renal function and serum in-flammatory factors.Methods One hundred patients with stage Ⅲ～Ⅳ diabetic kidney disease of syndrome of spleen-kidney Yang deficiency with blood stasis were selected from outpatient clinics and hospitalized in the Department of Endocrinology of the First Affiliated Hospital of Hebei University of Traditional Chinese Medicine from October 2021 to March 2023,and were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with irbesartan tablets on the basis of conventional western medicine treatment,while the observation group was treated with decoction for fortifying spleen,warming kidney and activating blood on the basis of the control group,both groups were con-tinuously treated for 12 weeks.The scores of Chinese medicine syndrome,quality of life[assessed by Adjusted Diabetes Quality of Life(A-DQOL)],levels of blood glucose indexes[fasting plasma glucose(FPG),2-h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c)],renal function indexes[serum creatinine(SCr),urinary excretion rate(UAER),glomerular filtration rate(eGFR),β2 microglutaments(β2-MG),cystatin C(Cys C)],and inflammation in-dexes[(interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]of the two groups before and after treatment were com-pared,and the clinical efficacy and occurrence of adverse reactions of the two groups were assessed.Results The scores of Chinese medicine syndrome,A-DQOL scores and the levels of FPG,2hPG,HbA1c,SCr,UAER,β2-MG,Cys C,IL-6 and TNF-α of the two groups were significantly lower after treatment than those before treatment(all P<0.05),and the a-bove indexes of the observation group after the treatment were significantly lower than those of the control group(all P<0.05);The eGFRs of the two groups were significantly higher after treatment than those before treatment(both P<0.05),and the observation group was significantly higher than the control group(P<0.05).After12 weeksoftreatment,thetotal effective rate of the observation group was 88%(44/50),which was significantly higher than that 68%(34/50)of the control group,the difference was statistically significant(P<0.05).No adverse reactions related to the drugs occurred in both groups during the treatment.Conclusion Decoction for fortifying spleen,warming kidney and activating blood com-bined with irbesartan is effective in the treatment of stage Ⅲ-Ⅳ diabetic kidney disease of syndrome of spleen-kidney Yang deficiency with blood stasis,which can significantly improve renal function,alleviate inflammatory responses,inhibit renal inflammatory injury,and improve quality of life.
decoction for fortifying spleen,warming kidney and activating blooddiabetic kidney diseasesyndrome of spleen-kidney Yang deficiency with blood stasisinterleukin-6tumor necrosis factor-α
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维普
