Correlation between Chinese medicine syndromes and renal pathology in 635 patients with idiopathic membranous nephropathy
Objective It is to explore the distribution of Chinese medicine syndrome types in patients with idiopathic membranous nephropathy(IMN)and their correlation with renal pathology.Methods The data of 635 patients who were diagnosed with IMN by nephronepuncture biopsy in Shaanxi Provincial Hospital of Traditional Chinese Medicine from 2008 to 2022 were retrospectively analyzed,and the syndrome types,pathological stages,and pathological characteristics of the patients were collected,and compared the differences and similarities among the syndrome types,pathological stages,and pathological characteristics were compared.Results The Chinese medicine syndromes were categorized into 6 types,the most was syndrome of spleen-kidney deficiency and wind-dampness harassing collaterals(39.84%),followed by syndrome of spleen deficiency and water flooding(36.38%),syndrome of Yang deficiency and mass accumulation(10.24%),syn-drome of spleen deficiency and dampness-heat(58 cases)(9.13%),syndrome of Qi-yin deficiency(2.68%),and syn-drome of water and blood stasis binding(1.73%).There were213 cases(33.70%)of stage Ⅰ membranous nephropathy,408 cases(64.25%)of stage Ⅱ membranous nephropathy,12 cases(1.89%)of stage Ⅲ membranous nephropathy,and 2 cases(0.32%)of stage Ⅳ membranous nephropathy.Syndrome of spleen deficiency and water flooding was more com-mon in stage Ⅰ and stage Ⅲ membranous nephropathy,syndrome of spleen-kidney deficiency and wind-dampness harassing collaterals was more common in stage Ⅱ membranous nephropathy;syndrome of Qi-yin deficiency and syndrome of water and blood stasis binding were not found in stage Ⅲ membranous nephropathy,and one case was syndrome of Qi-yin defi-ciency and one case was syndrome of water and blood stasis binding in the patients with stage Ⅳ membranous nephropathy.The Chinese medicine syndrome types were correlated with glomerulosclerosis and tubular atrophy(all P<0.05),and with the distributions of hyperplasia,hypertrophy,edema,lymphomononuclei,foam cells,vacuolar degeneration,and urinary cylinder(all P<0.05),but not with the distributions of glomerular adhesion,severe vacuolar degeneration,granular de-generation,regeneration,plasma cells,and periglomerular fibrosis(all P>0.05).Conclusion There is a correlation be-tween the Chinese medicine syndrome types and the renal pathological stage and some pathological characteristics in patients with IMN,which can provide some evidences for Chinese medical differentiation medication.
idiopathic membranous nephropathyrenal pathologyChinese medicine syndrome typepathological stagepathological characteristics
万方数据
维普
