Efficacy of decoction for replenishing Qi,activating blood and dispelling phlegm on asthma with OSAHS of syndrome of Qi deficiency and phlegm stasis
Objective It is to evaluate the clinical efficacy of decoction for replenishing Qi,activating blood and dispel-ling phlegm combined with western medicine in the treatment of patients with chronic persistent bronchial asthma and ob-structive sleep apnea hypoventilation syndrome(OSAHS)of syndrome of Qi deficiency and phlegm stasis.Methods Eighty patients with chronic persistent bronchial asthma and OSAHS of syndrome of Qi deficiency and phlegm stasis treated in Taizhou Fourth People's Hospital from January 2016 to June 2021 were selected,and were divided into control group and observation group according to the random number table,with 40 cases in each group.The control group was given conven-tional treatment and continuous positive pressure ventilation,and the observation group was treated with decoction for re-plenishing Qi,activating blood and dispelling phlegm on the basis of treatment in the control group.Both groups were con-tinuously treated for 3 months.The syndrome scores(including asthma,cough,sputum,snoring,wakefulness,daytime sleepiness,tiredness and fatigue),scores of Asthma Control Test(ACT),St.George's Respiratory Questionnaire(SGRQ),Epworth Sleepiness Scale(ESS),Pittsburgh Sleepiness Quotient Index(PSQI),pulmonary function indexes[peak expiratory flow(PEF),FEV1％,FEV1/FVC],polysomnographic parameters[apnea hypopnea index(AHI),rap-id eye movement(REM),oxygen desaturation index(ODI),SaO2,minimum SaO2,arousal index],inflammation-related indexes[serum levels of C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),vascular en-dothelial growth factor(VEGF),and level of exhaled exhaled nitric oxide(FeNO)]of the patients before and after treat-ment were observed in the two groups,the overall efficacy and the occurrence of adverse reactions in the two groups were calculated.Results The syndrome scores,SGRQ scores,ESS scores,PSQI scores,AHI,ODI,arousal index and levels of CRP,IL-6,TNF-α,VEGF in serum and exhaled FeNO of the two groups were significantly lower after treatment than those before treatment(all P＜0.05),and all the above indicators of the observation group were significantly lower than those of the control group(all P＜0.05);the ACT scores,PEF,FEV1％,FEV1/FVC,REM,SaO2,and minimum SaO2 of the two groups were all significantly higher than those before treatment(all P＜0.05),and all the above indicators of the ob-servation group were significantly higher than those of the control group(all P＜0.05).The total effective rate of the ob-servation group after 3 months of treatment was significantly higher than that of the control group[92.5％(37/40)VS.82.5％(33/40),P＜0.05],and the incidence rate of adverse reactions during the treatment period was significantly low-er than that of the control group[10.0％(4/40)VS.27.5％(11/40),P＜0.05].Conclusion Decoction for replenis-hing Qi,activating blood and dispelling phlegm combined with western medicine is more effective than western medicine a-lone in the treatment of bronchial asthma with obstructive sleep apnea hypoventilation syndrome patients with OSAHS of syn-drome of Qi deficiency and phlegm stasis,and it has obvious advantages in alleviating clinical symptoms,controlling asthma attacks,improving lung function and sleep quality,and its mechanism of action may be related to the inhibition of inflam-matory response.
bronchial asthmaobstructive sleep apnea hypopnea syndromesyndrome of Qi deficiency and phlegm stasisdecoction for replenishing Qi,activating blood and dispelling phlegminflammatory response
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