Efficacy of Fanbei Sanjie granules combined with chemotherapy on lung metastasis of colorectal cancer of syndrome of phlegm and blood binding
Objective It is to observe the clinical efficacy of Fanbei Sanjie granule in the treatment of patients with lung metastasis of colorectal cancer of syndrome of phlegm and blood binding.Methods A total of 84 patients with lung metasta-sis of colorectal cancer of syndrome of phlegm and blood binding treated in the Oncology Department of Yantai Hospital of Traditional Chinese Medicine were selected and divided into treatment group and control group according to the random number table,with 42 cases in each group.The control group was treated with mFOLFOX6 chemotherapy regimen,and the treatment group was treated with Fanbei Sanjie granule on the basis of the control group,14 days as one treatment cycles,and both groups were treated for 8 cycles.and the clinical efficacy of the two groups was observed and compared.The tumor control efficacy,scores of traditional Chinese medical syndromes,quality of life[assessed by EORTC QLQ-C30(V3.0)and KPS scores],immune function(CD4+,CD8+,CD4+/CD8+)before and after treatment,and the occur-rence of adverse reactions of chemotherapy of the patients were compared between the two groups.Results After 8 treatment cycles,there was no statistical significance in the objective response rate and disease control rate of patients between the two groups(both P＞0.05);the scores of traditional Chinese medical syndromes,and the scores of fatigue,pain,short-ness of breath,loss of appetite,and diarrhea in the EORTC QLQ-C30(V3.0)scale in the treatment group were signifi-cantly lower than those before treatment and in the control groups(all P＜0.05),and the scores of physical function,role function,emotional function,and general health status in the EORTC QLQ-C30(V3.0)scale were significantly higher than those before treatment and in the control groups(all P＜0.05);the total effective rate of improvement of KPS score in the treatment group was significantly higher than that in the control group[82.05％(32/39)VS.55.26％(21/38),P＜0.05],and CD4+,CD4+/CD8+were significantly higher than that before treatment and in the control group(P＜0.05),while the degree of leukocyte decrease and the occurrence of diarrhea were significantly lower than those in the control group(all P＜0.05).Conclusion Fanbei Sanjie granules combined with mFOLFOX6 chemotherapy regimen can obviously im-prove clinical symptoms,immune function and quality of life,and reduce adverse reactions of patients with lung metastasis of colorectal cancer of syndrome of phlegm and blood binding.
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