Correlation between Chinese medicine syndrome and clinical indicators in type 2 diabetes mellitus in the elderly
Objective It is to explore the relationship between Chinese medicine syndrome types and clinical indicators in elderly patients with type 2 diabetes mellitus(T2DM).Methods The case data of 446 elderly T2DM patients hospital-ized in the Department of Endocrinology of the First Affiliated Hospital of Henan University of Chinese Medicine from Janu-ary 2020 to January 2022 were collected,and the distribution of patients'Chinese medicine syndromes was counted to ana-lyze the correlations of Chinese medicine syndromes with gender,age,duration of disease,body mass index(BMI),an-kle-brachial index(ABI),fasting plsama glucose(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbAlc),total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipo-protein cholesterol(HDL-C),urinary microalbumin(UMA),and urinary microalbumin/creatinine ratio(UACR),and the statistically significant indexes were analyzed by multifactor Logistic analysis.Results The proportions of Chinese medi-cine syndrome types in elderly T2DM patients from high to low were as follows:syndrome of Qi-Yin deficiency,syndrome of damp-heat interaccumulation,syndrome of spleen deficiency and phlegm-dampness,syndrome of liver-kidney Yin deficien-cy,and syndrome of spleen-kidney Yang deficiency.There were significant differences in gender,age,disease duration,BMI,ABI distribution,2hPG,HDL-C,UMA and UACR among patients with different syndromes(all P＜0.05),and no significant differences in FPG,HbA1c,TC,TG and LDL-C(all P＞0.05).Multifactorial Logistic regression analysis showed that syndrome of Qi-Yin deficiency,syndrome of spleen deficiency and phlegm-dampness were positively correlated with age,syndrome of damp-heat interaccumulation was positively correlated with age;syndrome of damp-heat interaccumu-lation was negatively correlated with gender,syndrome of Qi-Yin deficiency,syndrome of spleen deficiency and phlegm-dampness were negatively correlated with gender;syndrome of spleen-kidney Yang deficiency was positively correlated with disease duration,syndrome of spleen deficiency and phlegm-dampness,syndrome of damp-heat interaccumulation,syn-drome of Qi-Yin deficiency,syndrome of liver-kidney Yin deficiency were negatively correlated with disease duration;syn-drome of spleen deficiency and phlegm-dampness,syndrome of liver-kidney Yin deficiency,and syndrome of spleen-kidney Yang deficiency were positively correlated with BMI,syndrome of Qi-Yin deficiency was negatively correlated with BMI;syndrome of spleen-kidney Yang deficiency was positively correlated with ABI;syndrome of damp-heat interaccumulation and syndrome of Qi-Yin deficiency were positively correlated with 2hPG,syndrome of spleen deficiency and phlegm-damp-ness was negatively correlated with 2hPG;syndrome of spleen deficiency and phlegm-dampness,syndrome of damp-heat in-teraccumulation,syndrome of Qi-Yin deficiency,syndrome of liver-kidney Yin deficiency were positively correlated with HDL-C,syndrome of spleen-kidney Yang deficiency was negatively correlated with HDL-C;syndrome of spleen-kidney Yang deficiency was positively correlated with UACR,syndrome of spleen deficiency and phlegm-dampness,syndrome of damp-heat interaccumulation,syndrome of Qi-Yin deficiency were negatively correlated with UACR.Conclusion Syndrome of Qi-Yin deficiency is the main syndrome type of T2DM in the elderly;the syndrome types were correlated with gender,age,disease duration,BMI,ABI distribution,2hPG,HDL-C,and UACR,in which gender,age,disease duration,BMI,2hPG,HDL-C,and UACR were the main indicators affecting the distribution of syndromes in elderly T2DM patients.
elderly type 2 diabetes mellitusChinese medicine syndromeclinical indicatorcorrelation
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