Effect of traditional Chinese medical treatment mainly for tonifying spleen on the prognosis of patients with stage Ⅱ-Ⅲ colorectal cancer of KRAS mutant
Effect of traditional Chinese medical treatment mainly for tonifying spleen on the prognosis of patients with stage Ⅱ-Ⅲ colorectal cancer of KRAS mutant
Objective It is to observe the effect of traditional Chinese medical treatment mainly for tonifying spleen on the prognosis of patients with stage Ⅱ-Ⅲ colorectal cancer of KRAS mutant.Methods A retrospective non-randomized con-temporaneous controlled study was conducted to collect data of 116 patients with stage Ⅱ-Ⅲ colorectal cancer of KRAS mu-tant treated in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine and Minhang Branch of Cancer Hospital of Fudan University from January 2015 to December 2021,and those who had continuously treated with tra-ditional Chinese medicine for ≥3 months were regarded as the treatment group,and those who had not received standard-ized traditional Chinese medicine treatment or the duration was＜3 months were regarded as the control group.The median disease-free survival(calculated by the Kaplan-Meier method)and the 1-,2-,3-,and 5-year disease-free survival rates of the patients were compared between the two groups,and the risk factors affecting the disease-free survival of the patients were analyzed.Results The median disease-free survival of the treatment group was 23.13 months,which was significantly longer than that 16.90 months of the control group(P＜0.05);the 1-,2-,3-,and 5-year disease-free survival rates of the treatment group were 83％,46％,40％,and 30％,respectively,those of the control group were 67％,38％,18％,and 6％respectively,and the disease-free survival rates of the treatment group were significantly higher than those of the control group(all P＜0.05).Traditional Chinese medicine treatment was an independent protective factor for the disease-free sur-vival(P＜0.05),and intravascular cancer thrombus was an independent risk factor for the recurrent metastasis of the pa-tients(P＜0.05),and the patients with lymph node stage N1 had a lower risk of recurrent metastasis compared with the patients with stage N2(P＜0.05).Conclusion Traditional Chinese medical treatment mainly for tonifying spleen can ef-fectively prolong the disease-free survival and reduce the recurrence and metastasis rates of patients with stage Ⅱ-Ⅲ color-ectal cancer of KRAS mutant;intravascular thrombus and regional lymph nodes are the high-risk factors for recurrence and metastasis in patients with stage Ⅱ-Ⅲ colorectal cancer of KRAS mutant.
关键词
健脾中药/KRAS突变/结直肠癌/无病生存期
Key words
traditional Chinese medical treatment for tonifying spleen/KRAS mutation/colorectal cancer/disease-free survival
维普
万方数据