Efficacy of acupuncture at myofascial trigger points combined with flunarizine hydrochloride on migraine
Objective It is to observe the efficacy of acupuncture at myofascial trigger points combined with flunarizine hydrochloride in the treatment of patients with migraine and its effects on inflammation-related indicators and vasoactive sub-stance.Methods Eighty migraine patients treated in Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from January 2017 to January 2022 were selected for the study,and the patients were divided into obser-vation group and control group according to the randomized numerical table method in the ratio of 1∶1,with 40 cases in each group.The control group was treated with sham acupuncture+oral administration of flunarizine hydrochloride,and the observation group was treated with acupuncture at myofascial trigger points combined with oral administration of flunarizine hydrochloride,the acupuncture was performed once every other day,and both groups were treated for 4 weeks.The head-ache,clinical efficacy,serum levels of inflammation-related indexes[cyclooxygenase-2(COX-2),calcitonin gene-related peptide(CGRP),prostaglandin E2(PGE2)],and vasoactive substances[vascular hemophilic factor(vWF),endothelin-1(ET-1),nitric oxide(NO)],cerebral blood flow velocity after treatment,and the incidence of adverse effects were com-pared between the two groups.Results After treatment,the times of migraine occurrences,the total duration of headache attacks,and the VAS score of pain in the observation group were significantly lower than those in the control group(all P<0.05);the total effective rate of the observation group was significantly higher than that of the control group[92.5%(37/40)VS.75.0%(30/40),P<0.05];the serum levels of COX-2,CGRP,PGE2,vWF,ET-1 in the observation group were significantly lower(all P<0.05),while the level of NO was significantly higher than those before treatment and in the control groups(all P<0.05);the blood flow velocities of the anterior cerebral artery,middle cerebral artery,posterior cerebral artery,vertebral artery,and basilar artery in the observation group were significantly slower than those before treat-ment and in the control groups(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion Acupuncture at myofascial trigger points com-bined with flunarizine hydrochloride is significantly effective in the treatment of migraine,which can effectively alleviate the pain symptoms of patients,reduce the level of inflammation-related indexes,improve vascular endothelial function and cer-ebral hemodynamics,and the treatment is safe.
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