Efficacy of Sancai Lianmei granules on type 2 diabetes mellitus and its effects on ghrelin and glucagon-like peptide-1
Objective It is to observe the efficacy of Sancai Lianmei granules in the treatment of patients with type 2 di-abetes mellitus with syndrome of Qi-Yin deficiency and its effect on ghrelin and glucagon-like peptide-1(GLP-1).Meth-ods Sixty patients with type 2 diabetes mellitus of syndrome of Qi-Yin deficiency with glycated hemoglobin(HbA1c)be-tween 6.5%and 10%treated in the Department of Endocrinology of the Affiliated Hospital of Chengdu University of Chi-nese Medicine from January to December 2022 were included,and were randomly divided into control group and experimen-tal group,with 30 cases in each group.Based on the individualized basic intervention,the control group was given met-formin hydrochloride tablets orally,while the experimental group was given Sancai Lianmei granules orally,both groups were treated continuously for 8 weeks.The glucose metabolism-related indexes[body weight,body mass index(BMI),HbA1c,blood glucose level of oral glucose tolerance test(OGTT),insulin level of insulin release test,C-peptide level,insulin resistance index(HOMA-IR),insulin secretion index(HOMA-β)]and serum levels of acylated ghrelin(AG),deacylated ghrelin(DAG),GLP-1 and scores of Chinese medicine syndromes and three-factor diet scale R21 of the two groups before and after treatment were compared,and the adverse events during the trial were recorded.Results After treat-ment,the body weight,BMI,levels of HbA1c and blood glucose at each time point of OGTT,HOMA-IR,serum level of AG and scores of Chinese medicine syndromes and three-factor diet scale R21 of the two groups were all significantly de-creased(all P<0.05);the levels of insulin at 1 h and 3 h in the insulin-release test in the experimental group were signif-icantly lower than those before treatment(both P<0.05),while HOMA-β and serum levels of GLP-1 and DAG were all significantly higher than those before treatment(both P<0.05);the levels of insulin at 0 h,1 h and 3 h in the insulin-re-lease test and the level of C peptide in the control group were significantly lower than those before treatment(all P<0.05).After treatment,the serum level of DAG of the experimental group was significantly higher than that of the control group(P<0.05),and the scores of Chinese medicine syndromes and three-factor diet scale R21 were significantly lower than those of the control group(all P<0.05),there was no significant differences in other indexes between the two groups(all P>0.05).No adverse events occurred in both groups during the trial period.Conclusion Sancai Lianmei granules can reduce blood glucose and body weight,improve insulin resistance and pancreatic β-cell function,effectively alleviate patients'symptoms,and reduce patients'appetite in patients with type 2 diabetes mellitus with syndrome of Qi-Yin defi-ciency,and these effects may be achieved by down-regulating the serum level of AG and up-regulating the level of GLP-1.
type 92 diabetes mellitusSancai Lianmei granulesghrelinglucagon-like peptide-1
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