Relationship between coronary plaque vulnerability and constitution of traditional Chinese medicine evaluated by intracoronary optical coherence tomography
Objective It is to evaluate the relationship between the characteristics of coronary plaque vulnerability and the constitution of traditional Chinese medicine(TCM)by coronary optical coherence tomography(OCT).Methods The OCT image data and TCM constitution data of patients diagnosed with coronary artery disease in the Department of Cardio-vascular Medicine of the Third Affiliated Hospital of Beijing University of Chinese Medicine from August 2022 to August 2023 were collected,and the patients were divided into the thin-cap fibroatheroma(TCFA)group and the non-TCFA group according to their coronary plaque condition,and the baseline data and the types of TCM constitution of the two groups were compared;the scores of phlegm-dampness constitution and whether the coronary plaque was TCFA were analyzed by ROC curve,and then the patients were divided into group of phlegm-dampness constitution score≥23.50 and group of phlegm-dampness constitution score<23.50 according to whether the phlegm-dampness constitution score was≥23.50,and the vulnerability characteristics of coronary plaques in the two groups were compared.Results There were no significant differ-ences in the gender,age,smoking and drinking history,hypertension and diabetes mellitus histories,and lipid levels be-tween patients of the TCFA group and non-TCFA group(all P>0.05),and the percentage of patients of phlegm-dampness constitution in the TCFA group was significantly higher than that in the non-TCFA group[18.00%(9/50)VS.2.94%(3/102),P<0.05].The analysis of ROC curves revealed the followings:the area under the curve(AUC)was 0.72[95%CI(0.64,0.81),P=0.04],the optimal cut-off value=23.50 points,and the sensitivity and specificity were 56.0%and 71.0%,respectively.The patients with phlegm-dampness constitution score≥23.50 had a greater probability of thin fiber caps(OR=4.26,P<0.05)and microchannel formation(OR=2.30,P<0.05).Conclusion Coronary plaque vulnerability in patients with coronary artery disease is closely related to phlegm-dampness constitution,and the higher the phlegm-dampness constitution score,the more likely the coronary plaque is vulnerable.
万方数据
维普
