Efficacy of decoction for fortifying spleen and resolving dampness combined with simethicone on overweight/obese type 2 diabetes mellitus and its effect on lipid accumulation index
Objective It is to explore the clinical efficacy of decoction for fortifying spleen and resolving dampness com-bined with simethicone in the treatment of patients with overweight/obese type2 diabetes mellitus(T2DM)and its effect on lipid accumulation product(LAP).Methods Sixty-eight cases of T2DM patients with syndrome of spleen deficiency and exuberant dampness treated in the Department of Endocrinology of Hebei Provincial Hospital of Traditional Chinese Medi-cine from September 2022 to September 2023 were collected,and were randomly divided into control group and observation group according to their order of medical consultation,with 34 cases in each group.The control group was treated with dia-betic lifestyle intervention and subcutaneous injection of simethicone,and the observation group was treated with decoction for fortifying spleen and resolving dampness orally based on the treatment of the control group,both groups were treated for 12 weeks.The primary and secondary symptom scores and total scores of syndrome,body weight,body mass index(BMI),waist circumference,LAP,blood glucose indexes[fasting plasma(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c)),insulin resistance index(HOMA-IR)],lipid indexes[total cholesterol(TC),tria-cylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]of patients in the two groups before and after treatment were compared,the overall treatment effects were assessed and the occurrence of adverse effects during the treatment period were counted in the two groups.Results After 12 weeks of treatment,the pri-mary and secondary symptom scores and total scores of syndrome,weight,WC,BMI,the levels of FPG,HOMA-IR,2hPG,HbAlc,TC,TG,LDL-c and LAP of patients in both groups were significantly lower than those before treatment(all P<0.05),and the these indexes in the observation group were significantly lower than those in the control group(all P<0.05);the HDL-C levels of patients in the two groups were higher than those before treatment(both P<0.05),and the observation group was significantly higher than the control group(P<0.05).After treatment,the total effective rate of the observation group was significantly higher than that of the control group[90.62%(29/32)VS.64.51%(20/31),P<0.05)].Conclusion Decoction for fortifying spleen and resolving dampness can effectively improve the clinical symptoms of overweight/obese T2DM patients with syndrome of spleen deficiency and exuberant dampness,and is helpful to reduce fat,weight,and body fat accumulation,control blood sugar and improve insulin resistance.
type 2 diabetes mellitusself-proposed decoction for fortifying spleen and resolving dampnessweight losslipid accumulation production
万方数据
维普
