Clinical efficacy of Tianchan capsule on cancer pain in advanced or locally advanced colorectal cancer
Objective It is to observe the clinical efficacy and safety of Tianchan capsule combined with opiates in the treatment of moderate and severe cancer pain in advanced or locally advanced colorectal cancer treating with chemotherapy(with or without targeted therapy).Methods Seventy cases of patients with cancer pain of colorectal cancer of type of Qi stagnation and blood stasis treated in the outpatient and inpatient departments of Cancer Hospital of China Academy of Tra-ditional Chinese Medicine,Sanhuan Cancer Hospital of Chaoyang District,inpatient department of Huanxing Cancer Hospi-tal of Chaoyang District,and inpatient department of Qinhuangdao Hospital of Traditional Chinese Medicine from April 2022 to June 2023 were selected and randomly divided into treatment group and control group,with 35 cases in each group,and finally 32 cases in the treatment group and 35 cases in the control group completed the trial.The treatment group was trea-ted with Tianchan capsule combined with opiates,while the control group was treated with placebo(1/10 active ingredients of Tianchan capsule and dextrin of traditional Chinese medicine)combined with opiates,both groups were treated for 14 days.The NRS score,BPI score,KPS score,QLQ-C30 score,Piper fatigue scale score,TCM syndrome score before and after treatment,daily dosage of opiates,TCM syndrome efficacy,cancer pain efficacy,and the occurrence of adverse reac-tions during treatment were compared between the two groups.Results On the 7th day of treatment,the NRS scores,total scores of the fatigue part of QLQ-C30 scale,scores of Piper fatigue scale of the two groups and the BPI score of the treat-ment group were significantly lower than those before treatment(all P＜0.05),the KPS score of the treatment group,the total scores of the health condition and quality of life of QLQ-C30 scale of the two groups were significantly higher than those before treatment(all P＜0.05),the differences in TCM syndrome scores of the two groups after treatment were not statisti-cally significant compared with those before treatment(both P＞0.05),and the difference in the above indicators after treatment were not statistically significant between the two groups(all P＞0.05).On the 14th day of treatment,the NRS scores,total scores of the fatigue part of QLQ-C30 scale,BPI scores,scores of Piper fatigue scale,TCM syndrome scores of the two groups were significantly lower than those before treatment(all P＜0.05),the KPS scores,total scores of the health condition and quality of life of QLQ-C30 scale of the two groups were significantly higher than those before treatment(all P＜0.05),the NRS score and TCM syndrome score of the treatment group were significantly lower than those of the control group in the same period(all P＜0.05).After treatment for 14 days,daily dosages of opiates were significantly lower than those on the first day of treatment in the two groups(both P＜0.05),but there was no significant difference be-tween the two groups(P＞0.05).After 14 days of treatment,the total effective rates of TCM syndrome in the treatment group and control group were 71.9％(23/32)and 42.9％(15/35),respectively,the pain relief rates in the treatment group and control group were 96.9％(31/32)and 71.4％(25/35),respectively,the differences were all significant dif-ferent between the two groups(all P＜0.05).The differences in the safety indexes such as blood routine,liver and kidney functions of the two groups before and after the treatment were not statistically significant(all P＞0.05).Conclusion Tian-chan capsule combined with opiates can enhance the analgesic effect in the treatment of moderate and severe cancer pain in advanced or locally advanced colorectal cancer treating with chemotherapy(with or without targeted therapy)with good safety.
万方数据
维普
