Efficacy of different administration modes of lesser abdomen stasis-expelling decoction on the sequelae of pelvic inflammatory disease of type of cold-damp stagnation
Objective It is to compare the clinical efficacies of different administration modes of lesser abdomen stasis-expelling decoction on the sequelae of pelvic inflammatory disease(SPID)of type of cold-damp stagnation and its influ-ences on serum complements and inflammation factors.Methods One hundred and five patients with SPID of type of cold-damp stagnation treated in Qingdao Hospital of Integrated Traditional Chinese and Western Medicine from July 2020 to March 2022 were randomly divided into control group,test group Ⅰ and test group Ⅱ,with 35 patients in each group,and were respectively treated with lesser abdomen stasis-expelling decoction by oral administration,enema and isolation medi-cine moxibustion,all the three groups were continuously treated for 3 menstrual cycles.The clinical manifestations(local signs and syndrome of traditional Chinese medicine)were observed,and the serum levels of complement(C3,C4)and in-flammation-related factors[(procalcitonin(PCT),interleukin-6(IL-6)]were detected in patients of the three groups be-fore and after treatment,and the occurrence of adverse drug reactions during treatment and the recurrence of the disease af-ter 6 months of drug withdrawal were recorded.Results One patient in each of the control group and test group Ⅰ dropped out and was not counted.After treatment,the total score of local signs and scores of single sign,the total score of tradition-al Chinese medicine syndrome and scores of single symptom of the three groups were significantly lower than those before treatment(all P＜0.05),and the total score of local signs and total score of traditional Chinese medicine syndrome of the test group Ⅱ were significantly lower than those of the control group and test group Ⅰ(all P＜0.05).After treatment,the serum levels of complement C3 of the three groups were significantly higher than those before treatment(all P＜0.05),while the serum levels of PCT and IL-6 were significantly lower than those before treatment(all P＜0.05),and the serum level of complement C3 of the test group Ⅱ was significantly higher than those of the control group and test group Ⅰ(both P＜0.05),while the serum level of IL-6 was significantly lower than those of the control group and test group Ⅰ(both P＜0.05).There were no adverse reactions occurred in the three groups during treatment.At the follow-up,the recurrence rate of test group Ⅱ was significantly lower than those of the control group and test group Ⅰ[14.28％(5/35)VS.41.17％(14/34),35.29％(12/34),both P＜0.05].Conclusion Isolation medicine moxibustion with lesser abdomen stasis-expelling decoction can more effectively regulate the immune function,alleviate the inflammatory reaction in the treat-ment of sequelae of pelvic inflammatory diseases of type of cold-damp stagnation,its clinical efficacy is remarkable with lower recurrence rate,and is better than those of oral or rectal administration of medicines.
lesser abdomen stasis-expelling decoctionsequelae of pelvic inflammatory diseaseisolation medicine moxibustionserum complementinflammatory factor
万方数据
维普
