Analysis of related factors of dry eye in patients with type 2 diabetes mellitus
Objective It is to observe the differences in related factors of dry eye in patients with type 2 diabetes melli-tus(T2DM)with different disease course HbA1c and TCM syndrome,and to explore the influence factors of dry eye in T2DM.Methods A total of 130 T2DM patients treated in Hebei General Hospital from January 2019 to January 2021 were selected and divided into＜10 year group(n=62)and≥ 10 year group(n=68)according to their courses of T2DM,and divided into Yin deficiency internal heat group(n=36),Qi-yin deficiency group(n=68),Yin-Yang deficiency group(n=26)according to their TCM syndromes,and 46 non-diabetic patients were set as control group.The gender,age and dry eye related indexes[SPEED score,lipid layer thickness(LLT),partial blink(PB),meibomian gland percentage(MGP),break-up time(BUT),tear secretion function(SIt),MGYLS score,MGYSS score)]were compared among the groups.Results There was no significant difference in gender and age among the groups(all P＞0.05).The MGP of dia-betic patients with different disease duration and HbA1c were significantly higher,while the MGYLS scores and MGYSS scores were significantly lower than those of the control group(all P＜0.05),and the SPEED scores of patients whose dis-ease coures≥10 years were significantly higher than the control group(P＜0.05),and BUT of patients whose disease coures≥10 years and HbA1c ≥7％were significantly lower than the control group(all P＜0.05).The LLT,SIt,PB and MGYLS scores of patients in different disease duration subgroups were not significant(all P＞0.05);the SPEED scores and MGP of patients in the≥10 year group were significantly higher while BUT and MGYSS scores were significantly lower than those in the＜10 year group(all P＜0.05).The PB of patients in different HbA1c subgroups were not significant(all P＞0.05);the BUT,SIt and MGYSS scores of patients with HbA1c ≥7％were significantly lower than those of pa-tients with HbA1c＜7％(all P＜0.05).The SPEED scores,SIt,and PB in patients of different TCM syndrome sub-groups were not significant(all P＞0.05);compared with Yin deficiency internal heat group,BUT was lower while MGP was higher in Qi-Yin deficiency group(all P＜0.05),LLT was lower while MGP was higher in patients in Yin-Yang defi-ciency group(all P＜0.05);the MGYLS score and MGYSS score were significantly higher in Yin-Yang deficiency group than those in Qi-Yin deficiency group(both P＜0.05).Conclusion The patients with T2DM have abnormal changes in the structure and function of meibomian gland with poor quality of tear film,which lead to various ocular surface discomfort,and the ocular surface discomfort and meibomian gland abnormalities are more severe in patients with poor glycemic control and longer course of disease,and are more likely to suffered from dry eye;Qi-Yin deficiency is more common in the pa-tients with blepharoplasty deficiency and shortened tear film breakup time.
type 2 diabetes mellitusdry eyetear filmmeibomian gland function
万方数据
维普
