Efficacy of decoction for raising Yang and replenishing stomach combined with SSRI antidepressants on depressive disorders
Objective It is to observe the efficacy of decoction for raising Yang and replenishing stomach combined with 5-HT selective serotonin reuptake inhibitor(SSRI)in the treatment of depressive disorders.Methods A total of 120 pa-tients with depressive disorders treated as outpatients or inpatients in Hebei Mental Health Center from December 2020 to May 2022 were divided into control group and observation group according to the random number table method,with 60 ca-ses in each group.The control group was treated with SSRIs,and the observation group was treated with SSRIs combined with decoction for raising Yang and replenishing stomach,both groups were treated continuously for 8 weeks.The scores of Hamilton Depression Scale(HAMD17),Hamilton Anxiety Scale(HAMA),Somatization Symptom Inventory(SSI),and Pittsburgh Sleep Quality Index(PSQI)after 2,4 and 8 weeks of treatment,as well as the therapeutic efficacy and adverse effects of the medications were compared between the two groups.Results Fifty-three cases in the control group and 55 ca-ses in the observation group completed the study.The HAMD17 scores,HAMA scores,and SSI scores of the two groups af-ter 2,4,and 8 weeks of treatment were significantly lower than those at baseline(all P<0.05),and the HAMD17 scores,HAMA scores,and SSI scores of the observation group after 2,4,and 8 weeks of treatment were significantly lower than those of the control group at the same time period(all P<0.05).The total PSQI scores and scores of sleep quality,sleep duration,sleep efficiency,and sleep performance after 8 weeks of treatment were significantly lower than those at baseline in the two groups(all P<0.05),and the total PSQI score and scores of sleep quality,sleep duration,sleep effi-ciency,hypnotic drugs,and daytime function scores of the observation group after 8 weeks of treatment were significantly lower than those of the control group at the same period(all P<0.05).The total effective rate of treatment in the observa-tion group was significantly higher than that in the control group in the same period after 2,4,and 8 weeks of treatment[52.7%(29/55),74.5%(41/55),and 89.1%(49/55)VS.39.6%(21/53),69.8%(37/53),and 81.1%(43/53),all P<0.05].The incidence of adverse reactions in the observation group was significantly lower than that in the control group[5.4%(3/55)VS.17.0%(9/53),P<0.05].Conclusion Decoction for raising Yang and replenishing stomach combined with SSRI drugs has a faster onset of action in the treatment of depressive disorders,and is more effective in improving depressive symptoms,anxiety symptoms,somatization symptoms and sleep quality with less adverse reactions.
ascending descending floating and sinking theorydecoction for raising Yang and replenishing stomach5-HT selective serotonin reuptake inhibitordepressive disorder
NETL
NSTL
万方数据
