外泌体在蚊媒黄病毒感染中的调控作用研究
Research on the regulation of exosomes in mosquito-borne flavivirus infection
罗瑶 1黄亚兰 2阳帆1
作者信息
- 1. 南方医科大学公共卫生学院,广东 广州 510515;深圳市疾病预防控制中心病原微生物检测所,深圳 518055
- 2. 深圳市疾病预防控制中心病原微生物检测所,深圳 518055
- 折叠
摘要
外泌体是一种广泛存在于人体体液中的由真核细胞分泌的一种细胞外囊泡,直径30～100nm.根据其生物发生和结构的特性,外泌体可以携带宿主细胞中的生物信息物质至其他细胞,在细胞间通信、生理病理反应中起着重要作用.受全球气候环境影响,蚊媒传染病逐渐对人类健康造成威胁,其中一种重要的病原体为黄病毒科病毒,包括登革病毒、寨卡病毒和流行性乙型脑炎病毒等.外泌体在黄病毒感染的过程中起着至关重要的作用,可促进病毒传播或激活宿主的免疫反应对抗病毒.本文主要总结了外泌体在蚊媒黄病毒科病毒感染中发挥调控作用的研究进展,以便更深入地了解病毒与宿主细胞的相互作用,从而开发出可作为防治蚊媒传染病的候选细胞靶点.
Abstract
Exosomes are extracellular vesicles that are widely present in human body fluids and secreted by eukaryotic cells,with a diameter of about 30-100nm.According to their biogenetic and structural characteristics,exosomes can carry biological information from host cells to other cells,and play an important role in intercellular communication and physiological and pathological reactions.Affected by the global climate and environment,mosquito-borne infectious diseases are gradually posing a threat to the health of more and more people.One of the important pathogens is faviviridae virus,including dengue virus,Zika virus and encephalitis B virus..Several studies have found that exosomes play a crucial role in the process of flavivirus infection,which may promote the transmission of the virus or activate the host immune response against the virus.In this paper,we summarized the research progress on the regulatory role of exosomes in mosquito-borne flavivirus infection,in order to better understand the interaction between viruses and host cells,so as to develop candidate cell targets for the prevention and control of mosquito-borne infectious diseases.
关键词
外泌体/蚊媒传染病/黄病毒科病毒Key words
Exosome/Mosquito-borne infectious diseases/Flavivirus引用本文复制引用
基金项目
深圳市医疗卫生三名工程项目(SZSM202211023)
病原微生物生物安全国家重点实验室开放基金(SKLPBS2244)
出版年
2024
国家科技期刊平台
NSTL
万方数据