神经梅毒的诊疗进展
Progress in diagnosis and treatment of neurosyphilis
王启征 1赵宇 1盛琪1
作者信息
- 1. 深圳市第三人民医院神经内科,广东 深圳 518000
- 折叠
摘要
21世纪以来,全球范围内梅毒的发病率和患病率均在逐年升高,因梅毒的特殊传播途径使其成为严重的社会公共健康问题.与此同时,神经梅毒的发病率也随之不断升高,梅毒螺旋体对神经系统的损伤表现多种多样,感染早期更是缺乏临床特异性,如诊治不及时,将对神经系统结构和功能造成不可逆性损害,严重者甚至会失能失智.目前对神经梅毒的分类可以根据是否存在临床症状分为有症状性神经梅毒和无症状性神经梅毒;根据感染的时间分为早期神经梅毒和晚期神经梅毒,对神经梅毒的确诊主要依据脑脊液的实验室检查结果.本文着重对近年来神经梅毒的流行病学、临床表现、诊断和治疗进展等进行归纳总结,以提高临床医生对该病的诊治水平.
Abstract
Since the beginning of the 21st century,the incidence rate and prevalence of syphilis have increased year by year worldwide.Due to its unique transmission route,syphilis has become a serious social public health problem.At the same time,the incidence rate of neurosyphilis also continues to set new records.Treponema pallidum has various manifestations of damage to the nervous system,especially in the early stage of infection.If the diagnosis and treatment is not timely,it will cause irreversible damage to the structure and function of the nervous system,and even disability and dementia in serious cases.At present,neurosyphilis can be classified into symptomatic neurosyphilis and asymptomatic neurosyphilis based on the presence of clinical symptoms,or into early neurosyphilis and late neurosyphilis based on the time of infection.The diagnosis of neurosyphilis is mainly based on the results of laboratory examination of cerebrospinal fluid.This article focuses on summarizing the epidemiology,clinical manifestations,diagnosis and treatment progress of neurosyphilis in recent years,in order to improve the diagnosis and treatment skills of clinicians for this disease.
关键词
梅毒/神经梅毒/诊断/治疗Key words
Syphilis/Neurosyphilis/Diagnosis/Treatment引用本文复制引用
基金项目
深圳市第三人民医院学科带头人启动基金(G2022160)
出版年
2024
国家科技期刊平台
NSTL
万方数据