血清sFlt-1、sCD163水平对重症支原体肺炎患者预后的预测价值
Predictive value of serum sFlt-1 and sCD163 levels for the prognosis of patients with severe mycoplasma pneumonia
路兴中 1曹丹丹 1李明华 2陈丽英2
作者信息
- 1. 齐齐哈尔市中医医院儿科,黑龙江 齐齐哈尔 161000
- 2. 齐齐哈尔市第一医院儿科,黑龙江 齐齐哈尔 161000
- 折叠
摘要
目的 探讨血清可溶性血管内皮生长因子受体1(soluble vascular endothelial growth factor receptor 1,sFlt-1)、可溶性血红蛋白清道夫受体 163(soluble hemoglobin scavenger receptor 163,sCD163)在重症支原体肺炎(mycoplasma pneumonia,MPP)患者中的表达水平,分析其预测MPP预后的价值.方法 选取2021年10月至2023年10月于齐齐哈尔市中医医院就诊的MPP患者249例(MPP组)作为研究对象,根据MPP患者病情严重程度,将患者分为轻症组145例与重症组104例,根据预后情况将104例重症组患者分为预后不良组30例与预后良好组74例.选取同期于本院体检健康者250例作为对照组.收集研究对象相关临床资料,酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)法检测血清sFlt-1、sCD163水平.多因素Logistic回归分析影响重症MPP患者预后的因素;受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析血清sFlt-1、sCD163对重症MPP患者预后的预测价值.结果 MPP组患者血清sFlt-1、sCD163水平显著高于对照组(P＜0.05).重症组患者血清sFlt-1、sCD163水平显著高于轻症组(P＜0.05).预后不良组患者血清sFlt-1、sCD163、C反应蛋白(C reactive protein,CRP)水平显著高于预后良好组(P＜0.05).多因素Logistic回归分析结果显示,sFlt-1、sCD163是重症MPP患者发生预后不良的危险因素(P＜0.05).R0C曲线结果显示,血清sFlt-1、sCD163水平单独及联合预测重症MPP患者预后不良的AUC分别为0.846、0.854、0.923,且二者联合优于单独预测(Z=2.656、2.519,P＜0.05).结论 血清sFlt-1、sCD163升高与重症MPP患者预后不良密切相关,且对患者预后不良有一定的预测价值.
Abstract
Objective To investigate the expression levels of serum soluble vascular endothelial growth factor receptor 1(sFlt-1)and soluble hemoglobin scavenger receptor(sCD163)levels in patients with severe mycoplasma pneumonia(MPP),and to analyze their value in predicting the prognosis of MPP.Method A total of 249 MPP patients(MPP group)who visited our hospital from 0ctober 2021 to 0ctober 2023 were collected as the study subjects,according to the severity of MPP patients'condition,they were separated into a mild illness group of 145 cases and a severe illness group of 104 cases,according to the prognosis,severe patients were grouped into a poor prognosis group of 30 cases and a good prognosis group of 74 cases.Clinical data related to the study subjects were collected,enzyme linked immunosorbent assay(ELISA)was applied to detect serum levels of sFlt-1 and sCD163.Multivariate Logistic regression was applied to analyze the factors affecting the prognosis of severe MPP patients.Receiver operating characteristic(R0C)curve was applied to analyze the predictive value of serum sFlt-1 and sCD163 for poor prognosis in severe MPP patients.Result The serum levels of sFlt-1 and sCD163 in the MPP group were obviously higher than those in the control group(P＜0.05).The serum levels of sFlt-1 and sCD163 in the severe group were obviously higher than those in the mild group(P＜0.05).The serum levels of sFlt-1,sCD163,and CRP in the poor prognosis group were obviously higher than those in the good prognosis group(P＜0.05).The results of multivariate Logistic regression analysis showed that sFlt-1 and sCD163 were risk factors for poor prognosis in severe MPP patients(P＜0.05).ROC curve results showed that the AUC of serum sFlt-1 and sCD163 levels alone and in combination in predicting poor prognosis in severe MPP patients was 0.846,0.854,and 0.923,respectively,and the combination of the two was better than the single prediction(z=2.656,2.519,P＜0.05).Conclusion Elevated serum sFlt-1 and sCD163 are closely related to poor prognosis in patients with severe MPP,and have certain predictive value for poor prognosis.
关键词
可溶性血管内皮生长因子受体1/可溶性血红蛋白清道夫受体/重症支原体肺炎/预后Key words
Soluble vascular endothelial growth factor receptor 1/Soluble hemoglobin scavenger receptor/Severe mycoplasma pneumonia/Prognosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据