Analysis of clinical characteristics and prognosis of cases of human to human severe fever with thrombocytopenia syndrome
王惠 1胡立芬 2董静 1陈玲 1薛平 1储雪琴2
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作者信息
1. 安徽省公共卫生临床中心感染病科,安徽 合肥 230000
2. 安徽医科大学第一附属医院感染病科,安徽 合肥 230000
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摘要
目的通过调查一起发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)聚集性疫情,分析其临床特征及预后,为SFTS聚集性疫情的识别、诊断、人际传播链及防控措施提供依据.方法根据确诊指标展开病例搜索,收集本组病例基本信息、发病情况、临床症状、诊断与治疗及预后等资料.对2023年11月安徽省合肥市的一起SFTS聚集性疫情的发生原因、传播途径、临床症状表现、诊断与治疗及预后特征进行分析.结果本次聚集性疫情涉及原发病例1例,继发病例10例,为家庭聚集性病例;10例继发病例均存在肝功能不全,其中8例患者伴有血小板及白细胞减少,5例患者出现凝血功能异常、肌红蛋白升高,7例患者尿蛋白呈阳性,4例患者尿隐血检查阳性,3例患者出现肾功能不全;10例继发病例中,9例好转,1例死亡.结论本组SFTS聚集性疫情,SFTS流行特征明显,临床特征典型,应引起重视,加强对SFTS死亡患者的管理,有利于降低人际传播风险.
Abstract
0bjective Through the investigation of a cluster epidemic of fever accompanied by thrombocytopenia syndrome,this study analyzes its clinical characteristics and prognosis to provide evidence for the identification,diagnosis,interpersonal transmission chain,and prevention measures of SFTS cluster epidemics.Method Case searches were conducted based on confirmed indicators,and basic information,incidence,clinical symptoms,and prognosis of the group were collected.Analysis of the causes,transmission routes,clinical symptoms,diagnosis and treatment,and prognostic characteristics of a clustered SFTS outbreak in Hefei,Anhui Province in November 2023.Result This cluster epidemic involved one primary case and ten secondary cases,all of which were family cluster cases.All ten patients had liver dysfunction,eight had thrombocytopenia and leukopenia,five had abnormal coagulation function and elevated myoglobin,seven had positive urine protein,four had hematuria,and three had renal dysfunction;among the 10 secondary cases,9 improved and 1 died.Conclusion This group of SFTS cluster epidemics has obvious epidemiological characteristics and typical clinical features,which should be taken seriously.Strengthening the management of SFTS fatalities is conducive to reducing the risk of interpersonal transmission.
关键词
发热伴血小板减少综合征/聚集性/人际传播/临床特征/预后
Key words
Severe fever with thrombocytopenia syndrome/Cluster outbreak/Human-to-human transmission/Prognosis/Clinical features
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