Objective:Numerous clinical studies have suggested that remnant cholesterol(RC)is closely related to the risk of cardiovascular disease.The purpose of this study is to further explore the correlation between RC and drug eluting stents(DES)restenosis.Methods:The present study retrospectively enrolled patients with acute coronary syndrome(ACS)who underwent DES implantation in our hospital from January 2016 to December 2020 and underwent coronary angiography at 18-30 months after intervention.According to the results of coronary angiography,the enrolled population was divided into in-stent restenosis(ISR)group and non-ISR group.Subsequently,the correlation between RC and DES-ISR was evaluated using a multiple regression analysis model.Finally,a receiver operating characteristic(ROC)curve was created to evaluate the ability of RC to predict DES-ISR.Results:A total of 603 ACS patients were included in this study,of which 69 had DES-ISR during follow-up.Compared with the non-ISR group,the RC concentration level in the ISR group was significantly higher[0.45(0.37,0.63)vs.0.37(0.27,0.48mmol/L),P＜0.001].In univariate regression analysis,RC was significantly correlated with DES-ISR(OR=3.620,95％ CI:1.817-7.211,P＜0.001);After adjusting for other mixed factors through a multivariate regression analysis model,RC remained independently correlated with DES-ISR(OR=3.255,95％ CI:1.562-6.659,P=0.002).Finally,through ROC curve analysis,it was found that RC can effectively predict the probability of DES-ISR in ACS patients in the medium to long term after intervention(area under the curve=0.671,95％ CI:0.605-0.736,P＜0.0001).
关键词
残余胆固醇/药物洗脱支架/急性冠状动脉综合征/支架内再狭窄/中远期
Key words
Remnant cholesterol/Drug-eluting stents/Acute coronary syndrome/In-stent restenosis/In the medium to long term
维普
万方数据