摘要
目的:分析40岁以下单纯舒张期高血压(isolated diastolic hypertension,IDH)与颈动脉斑块负荷评分(total burden score,TBS)的关系,探讨IDH是否对动脉粥样硬化发生发展产生影响.方法:观察对象为参加了 2010年至2018年间,至少一次随访,且接受了颈动脉超声检查的开滦研究队列人员1 336名.采用Logistic回归分析总人群及不同性别人群IDH对TBS增高的影响.结果:符合入选标准最终纳入1 236例.IDH组平均TBS高于正常血压组,分别为2.96分和2.55分.多因素Logistic结果显示,总人群IDH与TBS增高无相关性(P＞0.05).而在40岁以下男性人群中,IDH组TBS增高的风险比正常血压人群高7.1％(P＜0.05),在40岁以下女性人群中差异无统计学意义(P＞0.05).结论:40岁以下人群IDH与TBS的关联具有性别依赖性,其中男性人群IDH是TBS增高的影响因素,在女性人群无明显影响.
Abstract
Objective:To analyze the relationship between isolated diastolic hypertension(IDH)and total burden score(TBS)under 40 years of age and whether IDH has an effect on the development of atherosclerosis.Methods:Participants in the Kailuan study cohort who attended at least one follow-up between 2010 and 2018 and had carotid ultrasound.Logistic regression was used to analyze the effect of total population and different sex population IDH on the increase of TBS.Results:Final inclusion of 1 236 statistical analyses in accordance with inclusion criteria.The average TBS of IDH group was higher than that of normal blood pressure group,2.96 and 2.55,respectively.The multivariate Logistic results showed that there was no significant correlation between IDH and TBS increase in the total population(P＞0.05).The risk of increased TBS in the IDH group was 7.1％(P＜0.05)higher than that in the normal blood pressure group in the male group under 40 years of age.But there was no significant difference in the female group under 40 years of age(P＞0.05).Conclusions:The association between IDH and TBS in people under 40 years of age is sex-dependent,that IDH is positively correlation between IDH and TBS in male population,and there is no obvious effect in female population.
维普
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