Objective:To analyze whether the increase of plasma soluble growth stimulation expressed gene 2(sST2)level is correlated with unsuccessful weaning from extracorporeal membrane oxygenation(ECMO)in patients undergoing cardiac surgery.Methods:Data of patients who received ECMO support for postcardiotomy cardiogenic shock between January 2017 and July 2019 were retrospectively collected from Beijing Anzhen Hospital.Results:Ultimately,116 patients were included in the present study for analysis.Among them,87 people were successfully weaning from ECMO,and 29 people were unsuccessful weaning.Compared with successful weaning group,the lactate level(2.5 vs.4.9 mmol/L,P=0.001),BNP level(401.5 vs.1 326.5 ng/L,P=0.001),and prothrombin time(PT)(15.1 vs.17.5s,P=0.024)after 24 hours of ECMO support were higher in the unsuccessful weaning group.The proportion of patients with hypertension in the successful weaning group was higher than that in the unsuccessful weaning group(54.0％ vs.27.6％,P=0.014).Multivariate logistic regression analysis showed that increased sST2 and BNP levels were independent risk factors for unsuccessful weaning from extracorporeal membrane oxygenation in patients undergoing cardiac surgery(P＜0.05).Conclusions:Increased sST2 level is an independent risk factor for unsuccessful weaning from extracorporeal membrane oxygenation in patients undergoing cardiac surgery.
维普
万方数据