Objective:To observe the expression of protectin Dl in patients with acute decompensated heart failure and its relationship with prognosis.Methods:A total of 476 patients with chronic heart failure were were divided into non acute attack group(n=322)and acute attack group(n=154).Measure the serum levels of protectin D1 in two groups of patients,and analyze the evaluation effect of protectin D1 on the prognosis of patients with acute attack of chronic heart failure.Results:Compared with non acute attack group,the expression of protectin D1 in acute attack patients was significantly reduced[(488.6±172.9)vs.(146.3±71.8)μg/L,P＜0.05];The age,NYHA grade,FBG,NT-proBNP,all-cause mortality,and composite event incidence of patients in the low expression of protectin Dl group were significantly higher than those in the high expression of protectin D1 group(P＜0.05),while the ejection fraction was significantly lower than that in the high expression of protectin D1 group(P＜0.05).Kaplan Meier analysis showed that the incidence of all cause death and c composite event incidence in patients with low expression of protectin D1 group was significantly higher than that in patients with high expression of protectin D1 group(P＜0.05);The ROC curve results indicate that serum protectin D1 content has predictive value for composite event incidence in patients with acute attack of chronic heart failure(area under the curve is 0.882,P＜0.05).Conclusions:The content of serum protectin D1 in patients with acute attack of chronic heart failure was significantly decreased,and the content of protectin D1 is related to the prognosis of patients with acute attack of chronic heart failure.
维普
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