Objective:To investigate the relationship between alkaline phosphatase-albumin ratio(APAR)and survival rate in patients with hypertrophic cardiomyopathy(HCM).Methods:A total of 354 patients with HCM treated in the Department of Cardiology of our hospital from January 2017 to December 2020 were retrospectively included.The levels of serum alkaline phosphatase(continuous monitoring method)and albumin(transmission turbidimetry)were measured by automatic biochemical analyzer,and their ratio APAR was calculated.The main event was all-cause mortality and the secondary event was cardiovascular mortality.Results:During follow-up,a total of 44 patients reached the endpoint of all-cause death,of which 30(8.5％)were attributed to cardiovascular causes.The APAR of deceased patients on admission was significantly higher than that of survivors[1.76(1.27,2.24)vs.3.80(3.08,4.34),Z=-7.438,P＜0.001].The area under ROC curve of APAR for predicting all-cause death in HCM patients at admission was 0.846(95％CI:0.775-0.918),corresponding cutoff value was 2.88,specificity was 78.7％,and sensitivity was 84.1％.By Spearman rank correlation analysis,APAR was positively correlated with left ventricular end-diastolic outer diameter,resting left ventricular outflow tract gradient,left ventricular mass index,mitral regurgitation degree and left ventricular wall thickness,but negatively correlated with early diastolic peak flow velocity/late diastolic peak flow velocity(P＜0.05).Univariate and multivariate Cox regression analysis showed that APAR was an independent predictor of all-cause death in HCM patients(P＜0.05).Kaplan-Meier plots showed that the high APAR group had higher all-cause mortality(log.rank=7.103,P=0.008)and HCM-related mortality(log rank=1 1.366,P=0.001).Conclusions:High APAR at admission is associated with an increased risk of HCM death,and APAR holds promise as a reliable predictor of all-cause and HCM-related mortality in patients with HCM
维普
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