Objective:The role of inflammation in mood disorders in patients with Takayasu arteritis(TA)is unclear.The purpose of this study was to explore the association between inflammation-related risk factors and mood disorders in TA patients.Methods:A total of 59 patients diagnosed with TA in the Department of Rheumatology and Immunology at Beijing Anzhen Hospital between January 2021 and December 2021 were included in this study.Enrolled patients were divided into two groups according to whether they had mood disorders:mood disorder group(n=31)and mood disorder-free group(n=28).Univariate and multivariate Logistic regression analysis was used to determine the relationship between various inflammatory factors and mood disorders in TA patients.The association between statistically significant inflammatory factors and mood disorders were plotted according to the locally weighted scatterplot smoothing(Lowess).Results:White blood cell(P＜0.001),neutrophil(P=0.021),erythrocyte sedimentation rate(P=0.029),IL-(P＜0.001),IL-10(P=0.024)and TNF-α(P＜0.001)and interferon-y(P=0.003)significantly increased in TA patients with mood disorder.In the multivariate model,after adjusting for confounding factors,IL-6(OR=1.24,95％CI:1.02-1.50,P=0.030),IL-10(OR=3.12,95％CI:1.28-6.37,P=0.025)and TNF-α(OR=1.94,95％CI:1.03-3.66,P=0.040)were independently associated with the increased risk of mood disorders in TA patients.The results of Lowess curves were consistent with Logistic regression analysis:the incidence of mood disorders increased significantly with the increase of IL-6,IL-10 and TNF-α,respectively.Conclusions:The mood disorders of TA patients were closely related to inflammation.IL-6,IL-10 and TNF-α were independent risk factors.
维普
万方数据