Prognostic significance of the triglyceride-glucose index for patients with ischemic heart failure combined with type 2 diabetes mellitus after percutaneous coronary intervention
Prognostic significance of the triglyceride-glucose index for patients with ischemic heart failure combined with type 2 diabetes mellitus after percutaneous coronary intervention
Objective:Previous studies have established that the triglyceride-glucose(TyG)index is closely associated with the prognosis of cardiovascular diseases.However,the impact of the TyG index on the prognosis of patients with ischemic heart failure(HF)combined with type 2 diabetes mellitus(T2DM)undergoing PCI remains unclear.Methods:This retrospective study included 792 patients with ischemic HF and T2DM,divided into four groups based on quartiles of the TyG index.The primary endpoint was major adverse cardiovascular events(MACE),including all-cause mortality,non-fatal myocardial infarction(MI),and any revascularization.Kaplan-Meier survival analysis was used to assess the incidence of endpoints among the four groups.A multivariate Cox regression model analyzed the independent association of the TyG index with endpoints.Additionally,restricted cubic spline(RCS)analysis was conducted to examine the non-linear relationship between the TyG index and MACE.Results:The incidence of MACE significantly increased with higher baseline TyG levels(P＜0.001).Kaplan-Meier curves similarly indicated a significant increase in MACE incidence with higher baseline TyG levels(Log-rank P＜0.001).Multivariate Cox regression analysis revealed a significant increase in the risk of MACE with increasing baseline TyG levels(Group 1 as reference;Group 2 HR=1.24,95％CI:0.84-1.83,P=0.279;Group 3 HR=2.13,95％CI:1.47-3.08,P＜0.001;Group 4 HR=2.55,95％CI:1.76-3.68,P＜0.001).RCS curves showed a linear relationship between the TyG index and MACE outcomes,with the risk of MACE increasing as TyG levels increased(non-linearity P＞0.05).Conclusions:In patients with ischemic HF and T2DM undergoing PCI,the incidence of MACE significantly increased with higher TyG levels,showing a linear relationship.The TyG index is also an independent predictor of MACE in this population.These findings require further confirmation in prospective studies.
维普
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