Predictive value of growth differentiation factor-15 combined with silent information regulator 1 for prognosis in elderly patients with acute myocardial infarction after interventional therapy
Predictive value of growth differentiation factor-15 combined with silent information regulator 1 for prognosis in elderly patients with acute myocardial infarction after interventional therapy
Objective:To explore the predictive value of growth differentiation factor-15(GDF15)combined with silent information regulator 1(SIRT1)for prognosis in elderly patients with acute myocardial infarction(AMI)after interventional therapy.Methods:A total of 209 patients with AMI undergoing PCI in the hospital were enrolled as AMI group between January 2019 and August 2021,while 30 healthy controls during the same period were enrolled as control group.The expression levels of serum GDF15 and SIRT1 in AMI patients and control group were detected before and at 7d after surgery.The occurrence of major adverse cardiovascular events(MACE)within 3 months was observed.The differences in expressions of serum GDF15 and SIRT1 between patients with or without MACE were compared.And their predictive value for MACE was evaluated by receiver operating characteristic(ROC)curves.Results:Before and after surgery,level of serum GDF-15 in AMI patients was significantly higher than that in control group,and SIRT1 level was significantly lower than that in control group(P＜0.05).The area under the ROC curve(AUC)of GDF15 combined with SIRT1 in the diagnosis of AMI was significantly greater than that of single index(P＜0.05).In the 209 patients,there were 44 cases(21.1％)with MACE within 3 months after surgery.Before and after surgery,level of serum GDF-15 in patients with MACE was higher than that without MACE,and SIRT1 level was lower than that without MACE(P＜0.05).AUC of GDF15 combined with SIRT1 before surgery for predicting MACE was 0.816,significantly greater than that of single index(0.726,0.725,P＜0.05).AUC of GDF15 combined with SIRT1 after surgery for predicting MACE was 0.894,significantly greater than that of single index(0.815,0.811,P＜0.05).AUC of combined detection at 7d after surgery was greater than that before surgery(P＜0.05).Conclusions:The expression of serum GDF-15 is up-regulated,and SIRT1 is down-regulated in AMI patients.And their expression levels can predict MACE after PCI to certain extent and reflect prognosis of patients.
维普
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