Effect of lipoprotein(a)at different levels of high-sensitivity C-reactive protein on stroke recurrence in patients with ischemic stroke and hypertension
Effect of lipoprotein(a)at different levels of high-sensitivity C-reactive protein on stroke recurrence in patients with ischemic stroke and hypertension
Objective:This study examines the influence of lipoprotein(a)[Lp(a)]on recurrent ischemic stroke among hypertensive patients,stratified by levels of hs-CRP.Methods:A retrospective cohort study was conducted involving 318 individuals diagnosed with primary hypertension and ischemic stroke.Patients were categorized based on admission Lp(a)levels into low and high Lp(a)groups.The primary outcome was the recurrence of stroke within one year.The relationship between Lp(a)levels and stroke recurrence,overall and across varying hs-CRP strata,was assessed using multivariate Cox regression models.Hazard ratios(HR)with 95％confidence intervals(CI)were reported.Results:A notable increase in stroke recurrence was observed with elevated Lp(a)levels[low Lp(a):12,7.6％vs.high Lp(a):29,18.1％;P=0.008].Multivariate Cox regression analysis revealed a significantly higher risk of stroke recurrence in the high Lp(a)group across the entire cohort(HR=2.37,95％CI:1.18-4.77,P=0.016).This association was pronounced in patients with elevated hs-CRP levels(HR=2.78,95％CI:1.07-7.22,P=0.036),but was not statistically significant in those with lower hs-CRP levels(HR=2.17,95％CI:0.71-6.63,P=0.175).Conclusions:Elevated Lp(a)levels were markedly associated with an increased risk of stroke recurrence in individuals with ischemic stroke and primary hypertension.This risk was significantly heightened in the context of high hs-CRP levels,while no significant association was observed at lower hs-CRP levels.
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