Objective:To investigate the correlation between helicobacter pylori(HP)13C urea breath test positivity and the severity of coronary artery calcification.Methods:Participants were consecutively enrolled from June 2021 to November 2023 at a tertiary hospital's health examination center.A total of 485 individuals were included,with a mean age of(56.6±9)years,including 343 males(70.3％).HP testing results were collected for all participants,along with coronary artery computed tomography(CT)findings.Participants were divided into two groups based on their coronary artery calcium score(CACS):severe calcification group(CACS＞400,55 cases)and non-severe calcification group(CACS≤400,430 cases).Results:Among the 485 participants,126(26.0％)tested positive for HP infection.Coronary artery CT angiography(CTA)revealed severe coronary artery calcification(CAC score＞400)in 55 cases(11.3％).The severe calcification group had a significantly higher mean age compared to the non-severe calcification group[(63.5±8.9)vs.(55.6±8.8),P＜0.01].Smoking and alcohol consumption rates were higher in the severe calcification group,and there were statistically significant differences SBP,fasting blood glucose(FBG),and LDL-C levels between the two groups.The prevalence of HP infection differed significantly among individuals with different degrees of coronary artery calcification(P＜0.05).The mean 13C-urea breath test(UBT)value was(9.9±15.2)in the severe calcification group,with 41.8％testing positive,compared to a mean value of(135.5±9.9)and 23.8％positive in the non-severe calcification group(P＜0.05).The severe calcification group also had a significantly higher prevalence of carotid artery plaques compared to the non-severe calcification group.Additionally,the prevalence of severe coronary artery calcification was significantly higher in the HP-positive group compared to the HP-negative group(18.3％vs.8.9％,P=0.004).The HP-positive group had relatively higher heart rates and lower levels of HDL-C(P＜0.05).Multivariable Logistic analysis showed that age,smoking,and blood lipids were risk factors for coronary artery calcification.Compared to individuals negative for HP,those positive for HP had a higher relative risk of severe coronary artery calcification(OR=2.100,95％CI:1.094-4.029,P=0.026).Conclusions:After adjusting for traditional cardiovascular risk factors,individuals positive for HP have a relatively higher risk of coronary atherosclerosis.
维普
万方数据