Objective:To investigate the peripheral blood eosinophils(EOS)and serum total immunoglobulin E(IgE)in children with Kawasaki disease(KD).Methods:A total of 65 patients with KD were evaluated.Both in acute phase and remission phase,We determined the level of serum total IgE,the eosinophils counts from the complete blood count in two study groups.Another 22 children who were healthy were taken as control health group.Results:In KD group,the level of serum total IgE[282.6(94.2,454.5)IU/mL],the eosinophils counts[0.43(0.23,0.63)×109]and the percentage of eosinophils[4.7(2.4,6.8)％]in remission phase were higher compared to acute phase[160.7(15.4,302.0)IU/mL,0.34(0.13,0.57)xi09,3.3(1.6,5.1)％],and P was small than 0.05.Also,the level of serum total IgE,the eosinophils counts and the percentage of eosinophils in KD group were statistically significant higher compared to control health group[42.2(18.9,62.2)IU/mL,0.1(0.09,0.19)×109,2.7(1.3,4.0)％,P＜0.05].Children with allergic disease after KD(11)were more than that before KD(3).Conclusions:The counts and rates of EOS were found significantly higher in remission phase compared to acute phase.The development of Kawasaki disease is closely related to the allergic diseases.
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