Objective:To explore the safety and efficacy of Xuezhikang(XZK)in treating heterozygous with familial hypercholesterolemia(heFH).Methods:A total of 100 heFH treated in Anzhen Hospital from 2016-4 to 2019-12 were retrospectively studied.Patients were divided into two groups,50 cases each group.One group was treated with atorvastatin 20mg,and the other group was treated with XZK 0.6g twice a day.After 4 weeks,the changes of lipid level,liver and kidney function,creatine kinase and blood glucose were observed in two groups.Results:The TC and LDL-C of the two groups,TG in the observation group decreased significantly after 4 weeks treatment(P＜0.05).The level of TC,TG and LDL-C in the atorvastatin group decreased by 44.0％,37.7％,15.1％respectively after 4 weeks compared with that before treatment.TC and LDL-C level in the XZK group decreased by 41.5％,37.9％,21.4％respectively.There was significant difference in the range of TG reduction between two groups(P＜0.05);there was no significant change in liver and kidney function and creatine kinase in the observation group before and after treatment.Conclusions:XZK therapy could decrease levels of TC and LDL-C in heFH with good tolerance;it has been a safe and effective method for treating heFH.
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