Effect of myocardial hemorrhage on left ventricular remodeling after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction
Effect of myocardial hemorrhage on left ventricular remodeling after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction
Objective:The aim of this study was to investigate the impact of intramural hemorrhage(IMH)on adverse left ventricular remodeling following primary PCI in patients with acute ST elevation myocardial infarction(STEMI),in order to provide valuable insights for the treatment and management of patients with acute ST-elevation myocardial infarction(STEMI).Methods:A prospective cohort observational study was conducted involving 152 patients with acute STEMI undergoing direct PCI.Cardiac magnetic resonance(CMR)examination was performed within the first week post-primary PCI,and all patients were classified into two groups based on the presence or absence of IMH.Study patients was required to perform the second CMR 6 months after the primary PCI.CMR imaging was repeated at 6 months after primary PCI to observe changes in left ventricular end-diastolic volume(LVEDV)and Left ventricular remodeling was assessed,and the correlation between IMH and left ventricular remodeling was analyzed.Results:The result demonstrated that there was no significant improvement of LVEF in IMH group at 6 months after primary PCI(P＞0.05),whereas,there was a significant improvement in LVEF observed in the non-IMH group(P＜0.05).The proportion of left ventricular remodeling in IMH group was significantly higher compared with Non-IMH group[38.8％(26/67)vs.20.0％(17/85),P＜0.05],IMH were independent risk factors for left ventricular remodeling in acute STEMI patients undergoing PCI(P＜0.05).Conclusions:The IMH predicts unfavorable left ventricular remodeling at 6 months after primary PCI in patients diagnosed with acute STEMI.
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