Objective:To analyze the impact of sleep duration on chemotherapy-induced nausea and vomiting(CINV)in lung cancer patients by balancing confounding factors.Methods:A retrospective analysis was conducted on 950 inpatients in the Department of Oncology at the First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022.Patients were divided into two groups based on sleep duration before chemotherapy:Sleep duration＜7 hours group(536 cases)and sleep duration ≥ 7 hours control group(414 cases).Propensity score matching was performed in a 1∶1 ratio,resulting in 293 cases in each group.Baseline data were compared before and after matching,and conditional Logistic regression was conducted on the matched data to analyze the impact of sleep duration on CINV in lung cancer patients.Results:Before matching,there were statistically significant differences(P＜0.05)between the groups in terms of age,history of pregnancy-related nausea and vomiting,history of motion sickness,chemotherapy history,and use of platinum-based chemotherapy drugs.After matching,except for history of pregnancy-related nausea and vomiting,there were no statistically significant differences(P＞0.05)between the groups in other influencing factors.Conditional Logistic regression analysis showed that the incidence of CINV in the sleep duration＜7 hours group was 12.10 times higher than that in the control group(OR=12.10,95％CI:6.35-23.06,P＜0.001).Conclusion:Sleep duration＜7 hours is an independent risk factor for CINV in lung cancer patients.
关键词
肺癌/化疗/化疗相关恶心呕吐/倾向性评分匹配/睡眠
Key words
Lung cancer/Chemotherapy/Chemotherapy-induced nausea and vomiting/Propensity score matching/Sleep
维普
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