Objective:The common complication of PCI is in-stent restenosis(ISR).The incidence of ISR shows a significant gender difference.The triglyceride-glucose index(TyG)is considered a potential predictor of ISR.However,studies on the effectiveness of TyG in predicting ISR across different genders are limited.Methods:This single-center retrospective study included 257 patients diagnosed with atherosclerotic coronary artery disease at our Hospital between September 1,2017,and January 1,2019.Clinical baseline indicators and ISR occurrences were collected.The relationship between TyG levels and ISR incidence was analyzed across different genders.Multivariate logistic regression and restricted cubic splines were used to assess the correlation between TyG and ISR in different gender groups.Finally,receiver operating characteristic(ROC)curves and the area under the curve(AUC)were used to analyze the predictive efficacy of TyG for ISR in different gender groups.Results:The study included 197 male and 60 female patients,with 59 patients experiencing ISR.The results showed that the TyG index was an independent predictor of ISR in the overall population and in males,but not in females.The restricted cubic spline analysis showed that the OR for ISR started to increase significantly at TyG values around 9.0 in the overall and male populations.In contrast,there was no significant overall trend between TyG and ISR in the female population.ROC analysis showed that the predictive efficacy of TyG for ISR was higher in males(AUC=0.712)than in females(AUC=0.556).Conclusion:TyG index is a significant predictor of ISR in male patients but less effective in female patients,suggesting that gender differences should be considered when using TyG as a predictive indicator for ISR in clinical practice.
维普
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