Objective:To investigate the predictive value of estimated glucose disposal rate(eGDR)for recurrent stroke in patients with acute ischemic stroke(AIS)and diabetes.Methods:A total of 745 diabetic patients admitted to at the First Affiliated Hospital of Henan University of Science and Technology due to AIS from January 1st,2021 to January 1st,2023 were included in the study.Patients were categorized into four groups based on quartiles of eGDR and followed up for 12 months.The primary endpoint was the occurrence of recurrent ischemic stroke during the follow-up period.Univariate and multivariate Cox regression analyses were conducted to explore the impact of eGDR on recurrent stroke,and Kaplan-Meier survival curves were plotted.Forest plots were used to display the results of subgroup analyses.Restricted cubic spline(RCS)was constructed to present the linear relation between eGDR and recurrent stroke.Results:As eGDR increased,the incidence of recurrent stroke significantly decreased[Group 1 vs.Group 2 vs.Group 3 vs.Group 4:28(15.0％)vs.16(8.6％)vs.13(7.0％)vs.11(5.9％)].Kaplan-Meier analysis showed that the incidence of the recurrent stroke decreased gradually with rising eGDR quartiles(log-rank test,P=0.010).Multivariate Cox regression analysis revealed that compared with the lowest eGDR quartile,the top eGDR quartile was associated with significantly reduced risk of recurrent stroke(HR=0.433,95％CI:0.209-0.898,P=0.025).RCS demonstrated a linear relationship between eGDR and recurrent stroke,with a decreasing risk of recurrent stroke as eGDR increased.No significant interaction was observed in subgroup analysis.Conclusion:eGDR is an independent predictive factor for recurrent stroke in patients with AIS and diabetes.As eGDR increased,the risk of recurrent stroke was significantly decreased.
维普
万方数据