摘要
吗啡成瘾是一种慢性、复发性疾病,给个人和社会带来重大的健康、经济和社会问题.阻碍吗啡成瘾后戒断的主要因素是与成瘾药物相关的记忆持续存在.钙/钙调依赖性蛋白激酶Ⅱ(CaMKⅡ)是突触后致密物中巩固成瘾记忆的主要组成部分.现已证实CaMKⅡ在导致吗啡成瘾的记忆中发挥着重要作用,其参与CaMKⅡ调控吗啡成瘾的分子主要包括NMDAR、NO、Ng、TRPV1.其具体作用机制还不明确,仍需深入探究.
Abstract
Morphine addiction is characterized by compulsive drug use and a high rate of relapse,which cau-ses significant health,economic and social problems for individuals and society.The main factor abstinence after morphine addiction is the persistence of memories associated with the addictive drug.Calcium/calmodulin-de-pendent protein kinase Ⅱ(CaMKⅡ)is a major component of postsynaptic density,which is necessary for the con-solidation of addictive memories.It has been confirmed that CaMKⅡ plays an important role in memory-induced morphine addiction and the molecules involved in the regulation of morphine addiction by CaMKⅡ mainly include NMDAR,NO,Ng,TRPV1.However,the mechanism is still unclear and needs further exploration.
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