Morphine addiction is characterized by compulsive drug use and a high rate of relapse,which cau-ses significant health,economic and social problems for individuals and society.The main factor abstinence after morphine addiction is the persistence of memories associated with the addictive drug.Calcium/calmodulin-de-pendent protein kinase Ⅱ(CaMKⅡ)is a major component of postsynaptic density,which is necessary for the con-solidation of addictive memories.It has been confirmed that CaMKⅡ plays an important role in memory-induced morphine addiction and the molecules involved in the regulation of morphine addiction by CaMKⅡ mainly include NMDAR,NO,Ng,TRPV1.However,the mechanism is still unclear and needs further exploration.
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