首页|类风湿性关节炎实验模型的研究进展

类风湿性关节炎实验模型的研究进展

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类风湿性关节炎实验模型对于研究和发现治疗类风湿性关节炎的新药物和新疗法至关重要.归纳总结相关实验模型内容发现,胶原诱导关节炎模型在临床特征、实验室检测指标和发病机制上与类风湿性关节炎患者最为相近,被广泛应用于药物药效和作用机制的研究;病-症结合的关节炎模型能反应出中医辨证论治的特色,在中医药研究中被大量使用;成纤维样滑膜细胞模型主要应用于药物对滑膜细胞增殖和炎症反应的抑制研究,而破骨细胞模型则应用于药物对骨和软骨的保护研究.研究者需要结合自身研究方向和药物的作用特点选择合适的实验模型,以得到满意的实验结果.
Research Progress of Experimental Model of Rheumatoid Arthritis
Experimental models of rheumatoid arthritis are crucial to the research and discovery of new drugs and therapies for the treatment of rheumatoid arthritis.In this paper,the contents of commonly used experimental models are summarized,and it was found that the collagen-induced animal model was most similar to that of rheu-matoid arthritis patients in terms of clinical characteristics,laboratory detection indicators and pathogenesis and was widely used in the study of drug efficacy and mechanism of action.The animal model of the combination of disease and syndrome can reflect the characteristics of TCM syndrome differentiation and treatment and is widely used in TCM related research.The fibroblast-like synovial cell model is more commonly used to study the inhibition of synovial cell proliferation and inflammatory response by drugs while the osteoclast model is used to study the protec-tion of bone and cartilage by drugs.Researchers need to select a suitable experimental model according to their own research direction and the action characteristics of drugs to obtain satisfactory experimental results.

rheumatoid arthritisexperimental model

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湖北职业技术学院,湖北孝感 432000

类风湿性关节炎 实验模型

2024

湖北职业技术学院学报
湖北职业技术学院

湖北职业技术学院学报

影响因子:0.284
ISSN:1671-8178
年,卷(期):2024.27(4)