HMGB1在调节骨关节炎软骨细胞功能中的作用机制
Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes
齐鑫 1张晓刚 2于海洋 2陈欣 2安文博 2王志鹏 2王多贤 2罗鹏飞 2陈一新 1马姣姣 1齐伟 1胡紫阳 1刘建军2
作者信息
- 1. 甘肃中医药大学, 兰州 730000
- 2. 甘肃中医药大学附属医院, 兰州 730000
- 折叠
摘要
骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,其主要特征是关节软骨破坏,导致患者身体疼痛和残疾,严重影响其生活质量.OA可由多种病因诱发,而关节软骨的病理改变被认为是OA发生的关键驱动因素之一.高迁移率族蛋白1(high mobility group box-1 protein,HMGB1)作为一种真核细胞内的非组蛋白,可参与调节软骨细胞炎症及凋亡过程,从而导致关节软骨受损,诱发OA.本文就HMGB1 在OA软骨细胞中的作用机制进行综述,以期为临床防治OA提供新思路.
Abstract
Osteoarthritis(OA)is a chronic degenerative joint disease whose main characteristic is the destruction of articular cartilage,causing pain and disability in patients and seriously affecting their quality of life.OA can be induced by a variety of causes,and pathological changes in articular cartilage are considered to be one of the key driving factors for the occurrence of OA.High mobility group box-1 protein(HMGB1),as a non-histone protein in eukaryotic cells,can participate in regulating the inflammation and apoptosis process of OA chondrocytes,thus leading to the occurrence of OA.This article reviews the research on the mechanism of HMGB1 in OA chondrocytes,with a view to providing new ideas for the clinical prevention and treatment of OA.
关键词
骨关节炎/高迁移率族蛋白1/软骨细胞/信号通路Key words
osteoarthritis/high mobility group box-1 protein/chondrocytes/signal pathway引用本文复制引用
基金项目
全国名老中医药专家传承工作室建设项目张晓刚传承工作室项目(国中医药人教函[2022]75号)
卫生健康行业科研项目(2021)(GSWSKY-2021-069)
甘肃中医药大学研究生创新基金()
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据