中性粒细胞胞外陷阱在慢性阻塞性肺疾病中的作用
Role of Neutrophil Extracellular Traps in Chronic Obstructive Pulmonary Disease
许金回 1岳红梅 2刘苗苗 1李雅亭 1武兴东 1朱浩斌1
作者信息
- 1. 兰州大学第一临床医学院, 兰州 730000
- 2. 兰州大学第一临床医学院, 兰州 730000;兰州大学第一医院呼吸与危重症医学科, 兰州 730000
- 折叠
摘要
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种以中性粒细胞浸润所致炎症为特征的呼吸道疾病,目前已成为全球第三大死亡原因.发生COPD后,中性粒细胞持续聚集可促进中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)过度形成,在局部捕获与清除病原体、快速控制感染、免疫调节等方面发挥重要作用.本文主要介绍COPD发生与NETs形成机制以及NETs在COPD中的作用研究进展,并梳理基于NETs进行COPD治疗的相关药物靶点,以期为进一步研究提供参考.
Abstract
Chronic obstructive pulmonary disease(COPD),a respiratory disease characterized by in-flammation due to neutrophil infiltration,has become the third leading cause of death worldwide.After the oc-currence of COPD,the persistent accumulation of neutrophils can promote the excessive formation of neutrophil extracellular traps(NETs),which plays an important role in local capture and clearance of pathogens,rapid control of infection,and immune regulation.This article mainly introduces the mechanism of COPD occurrence and NETs formation as well as the research progress of NETs in COPD,and summarizes the relevant drug tar-gets for COPD treatment based on NETs,aiming to provide a reference for further research.
关键词
慢性阻塞性肺疾病/中性粒细胞胞外陷阱/靶向治疗/作用机制Key words
chronic obstructive pulmonary disease/neutrophil extracellular traps/targeted therapy/mechanism of action引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据