以血小板异常增高为表现的慢性粒细胞白血病合并脑出血患者成功救治一例
Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation
张鑫 1张笑 1郭毅 1冯俊 2肖志源 1解兆祥 1武静 1许冬蕊 1魏俊吉 1王裕1
作者信息
- 1. 中国医学科学院北京协和医院 神经外科, 北京 100730
- 2. 中国医学科学院北京协和医院 血液内科, 北京 100730
- 折叠
摘要
血小板升高为慢性粒细胞白血病(chronic myeloid leukemia,CML)患者外周血的罕见表现.本文首次报道 1 例以血小板异常增高为表现的CML合并脑出血病例.该患者外周血血小板升高,凝血功能正常,因脑出血行颅内血肿清除术,术后出现术区和其他系统出血,结合骨髓活检及基因检测确诊为CML.予以氟马替尼经空肠管给药后,患者病情得以控制,此项治疗尚属国内外首次报道.本文对该患者的诊治过程进行梳理,以期为临床医师提供警示与借鉴.
Abstract
Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic mye-loid leukemia(CML).In this paper,we report for the first time a case of CML combined with cerebral hemor-rhage manifested by abnormally elevated platelets.The patient had elevated platelets in the peripheral blood,showed normal coagulation function,and underwent intracranial hematoma removal due to cerebral hemorrhage.After the operation,bleeding from the operated area and other systems occurred,and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing.His condition was controlled after administration of flumatinib through a jejunal tube.Based on this patient's experience,the feasibility of administering flumatinib via a jejunostomy tube was determined,which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient,with the aim of provi-ding a warning and reference for clinicians.
关键词
脑出血/血小板增高/慢性粒细胞白血病Key words
cerebral hemorrhage/platelet elevation/chronic myeloid leukemia引用本文复制引用
基金项目
中央高水平医院临床科研专项(2022-PUMCH-032)
京津冀基础研究合作专项(19JCZDJC64600Z)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据