Research Progress of Multifocal/Multicentric Breast Cancer
刘佳 1周星彤 1孙强1
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作者信息
1. 中国医学科学院北京协和医院乳腺外科,北京 100730
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摘要
影像学技术的进步使得越来越多的多灶性/多中心性乳腺癌(multifocal/multicentric breast cancer,MMBC)在早期被发现.传统观念认为,MMBC比单灶性乳腺癌(unifocal breast cancer,UBC)预后更差,应积极升级治疗手段.近年来,随着医疗水平的提升,MMBC患者的诊断、个体化治疗、接受保乳手术的安全性等焦点问题需重新被审视.本文将从MMBC流行病学特征、术前影像学评估、病理异质性与分子标志物、手术方式等多方面展开论述,以期加深临床认知.
Abstract
Advances in imaging techniques have allowed an increasing number of multifocal/multicentric breast cancers(MMBC)to be detected at an early stage.Traditionally,MMBC has been considered to have a worse prognosis than unifocal breast cancer(UBC)and should be treated with escalation therapy.With the ad-vancement of medical technology in recent years,the diagnosis,individualized treatment strategies,and the safety of breast-conserving surgery for MMBC need to be re-examined.This paper reviews the epidemiologic fea-tures,preoperative imaging assessment,pathological heterogeneity,molecular markers,and surgical approaches of MMBC,so as to deepen the knowledge of clinicians.
关键词
多灶性/多中心性乳腺癌/影像评估/保乳治疗/肿瘤整形术
Key words
multifocal/multicentric breast cancer/imaging evaluation/breast conserving therapy/oncoplasty
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