Novel 18F-FES PET/CT in Non-invasive Functional Diagnosis of Delayed Lung Metastasis Presented with Horner Syndrome in a Metastatic Breast Cancer Patient
Novel 18F-FES PET/CT in Non-invasive Functional Diagnosis of Delayed Lung Metastasis Presented with Horner Syndrome in a Metastatic Breast Cancer Patient
Hormonal receptor positive human epidermal receptor 2 negative(HR+/HER2-)is the commonest molecular subtype of breast cancer(BC).Patients with HR+/HER2-BC may manifest clinically a late recurrence whose BC metastasizes 10-15 years post-operatively.We report one case who presented with pulmonary mass in upper lobe of lung and Horner syndrome 16 years after BC surgery.FDG PET/CT suggested pulmonary malignancy but could not differentiate between primary or metastatic cancer when invasive biopsy was quite risky.Novel 18 F-FES PET/CT facilitated the non-invasive functional diagnosis of estrogen-receptor positive(ER+)pulmonary metastasis of BC,and the patient experienced partial response(PR)after CDK4/6 inhibitor and aromatase inhibitor as endocrine therapy.This article reviews the diagnosis and treatment process of this case,to provide guidance for non-invasive global evaluation of ER status among metastatic HR+/HER2-BC patients with 18F-FES PET/CT.
关键词
乳腺癌/18F-FES/PET/CT/肺转移/霍纳综合征/雌激素受体
Key words
breast cancer/18F-FES PET/CT/pulmonary metastasis/Horner syndrome/estrogen receptor
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