首页|激光切割加工皮表微流控顺序汗液采样贴片

激光切割加工皮表微流控顺序汗液采样贴片

Laser Cutting for Epidermal Microfluidic Sequential Sweat Sampling Patches

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人体汗液包括丰富的生物标志,其浓度与人体生理状况和健康状态密切相关.皮表微流控贴片是进行汗液采样的理想平台.基于毛细压力爆破阀的顺序微流控汗液采样可以把汗液分时段存储在不同的储液池中,以便对不同时段的汗液信息进行分析,是进行微流控汗液采样的常用形式.但是传统的时序微流控汗液采样与传感器的加工依赖于软光刻技术,其加工成本较高,加工周期较长.激光切割加工微流控贴片具有快速、低成本、设计灵活性高等方面的优势,但是激光切割双面胶带难以获得小尺寸微通道,这限制了该技术在顺序汗液采样微流控贴片加工中的应用.通过对顺序采样微流控器件的结构进行优化设计,使其适合于激光切割加工,并把制作的贴片用于基于注射泵的液体收集和贴于人体皮肤的汗液采样实验,验证了微流控贴片的顺序采样的能力.提出的结构设计和加工方案可显著降低顺序汗液采样微流控贴片的加工成本,提升其加工效率,提高器件设计的灵活性.
The human sweat contained a rich array of biomarkers,and the concentrations closely linked to the individu-al's physiological and health status.The epidermal microfluidic patches presented an ideal platform for sweat sampling.The sequential microfluidic sweat sampling utilizing capillary burst valves allowed the temporal storage of sweat in different res-ervoirs,which enabled the analysis of sweat information from distinct time periods,and it was a commonly employed meth-od in microfluidic sweat sampling.However,traditional time-sequential microfluidic sweat sampling and sensor processing relied on soft lithography,which had higher processing costs and longer production cycles.The laser cutting of microfluidic patches offered advantages in terms of rapidity,low-cost,high design flexibility and so on.Nevertheless,small-sized micro-channels was obtained with difficulty with laser-cut double-sided adhesive tapes,which limited the application of this tech-nology in fabricating sequential sweat sampling microfluidic patches.We optimized the structure design of sequential sam-pling microfluidic devices for laser cutting,and validated the sequential sampling capability of the manufactured patches through experiments involving liquid collection of a injection pump based and sweat sampling on human skin.The proposed structural design and processing approach significantly reduced the manufacturing costs of sequential sweat sampling mi-crofluidic patches,enhanced processing efficiency,and improved device design flexibility.

epidermal microfluidicCBV valvessequential sweat samplinglaser cutting

魏磊、李震、张旭

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阜阳师范大学 物理与电子工程学院,安徽 阜阳 236037

皮表微流控 CBV阀 顺序汗液采样 激光切割加工

安徽省高等学校自然科学研究重点项目教育部产学合作协同育人项目安徽普通高校重点实验室开放课题阜阳师范大学课程思政示范课程教学研究项目阜阳师范大学优秀青年人才基金重点项目

2023AH050408230704810260232FMDI2023012023KCSZSF06rcxm202304

2024

新技术新工艺
中国兵器工业新技术推广研究所

新技术新工艺

影响因子：0.294
ISSN：1003-5311
年,卷(期)：2024.440(8)