Mammalian ovarian function depends on the interactions between the germ and somatic cell,and the regulation of several intraovarian autocrine/paracrine regulators in the ovary. These mediators regulate various ovarian cellular activities including cell growth, differentiation and apoptosis,which play critical role in follicular development. Micro-RNAs (miRNAs) are small, noncoding,single-strand regulatory RNAs that are 21 to 25 nucleotides in length. It was found that miRNAs play important roles in the posttranscriptional gene expression. It have indicated that miRNAs have the regulatory function in mice oocyte maturation and ovarian follicular development. In the human,miRNAs may affect the specific gene expression in granulosa cells and participate in the establishment and progression of ovarian cancer. This paper will review the miRNAs' biosynthesis, expression in mammalian reproductive system and the potential regulatory functions of miRNAs in the reproductive system under normal and pathologic conditions.
国家科技期刊平台
NSTL
万方数据
维普
