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山羊产羔数全基因组关联分析

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
本研究旨在通过对山羊产羔性状的全基因组关联分析(GWAS),寻找和定位与山羊产羔性状密切关联的新基因.以云南黑山羊6个公羊家系的302只山羊为试验材料,用Illumina公司Iselect Goat60k芯片技术进行SNP分型,分型结果利用plink V1.07的线性回归模型对山羊产羔数性状进行全基因组关联分析.研究结果表明:在2号染色体上有2个SNPs位点与山羊产羔数达到5％基因组水平显著相关(P＜1.48E-6),分别位于SLC4A10基因的下游和TBR1基因的上游;5个SNPs位点与山羊产羔数达潜在关联(P＜2.97E-5),分别位于1号染色体SENP7基因上游,21号染色体Hypothetical Protein基因的上游,以及28号染色体WDFY4基因和TMEM26基因的上游、BICC1基因的下游.这些基因可作为山羊产羔数性状的相关候选基因,也可为山羊产羔性状的分子机制研究和今后标记辅助选择的开展提供理论基础及新的研究线索.
Genome-wide Association Study of Lambing Number in Goat
The aim of this study was to find and map novel genes related to lambing number in goat by genome-wide association study(GWAS).A total of 302 Yunnan Black goats from 6 families were genotyped by Illumina Goat60K iSelect array.The GWAS on goat lambing number was performed.The Results showed that 2 SNPs located at the downstream of SLC4A10 and upstream of TBR1 on chromosome 2 were significantly associated with lambing number (P＜1.48E-6) at 5 ％ genome-wide level.Five SNPs were suggestive associated with lambing number (P＜2.97E-5).These 5 SNPs were located on chromosome 1,21,28,respectively,including SENP7,Hypothetical Protein,WDFY4,TMEM26 and BICC1 genes.These genes and SNPs offer essential information for understanding the molecular mechanisms of lambing number and provide foundation for the application of marker-assisted selection in breeding program of goat.

Yunnan Black goatlambing numbergenome-wide association study

兰蓉、朱兰、姚新荣、王鹏、邵庆勇、洪琼花

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云南省畜牧兽医科学院,昆明650224

云南省种羊繁育推广中心,寻甸650000

云南黑山羊 产羔数 全基因组关联分析

国家现代农业产业技术体系建设专项云南省科技计划项目

CARS-392014BB014

2015

10.11843/j.issn.0366-6964.2015.04.006

畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCDCSCD北大核心
影响因子：0.729
ISSN：0366-6964
年,卷(期)：2015.46(4)
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