肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用
Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury
王鑫鑫 1林树梅 1赵冬冬 1王学生2
作者信息
- 1. 沈阳农业大学动物科学与医学学院,沈阳 110866
- 2. 沈阳康利生物科技有限公司,沈阳 110000
- 折叠
摘要
外泌体作为细胞间微环境中的信使,能够将信号在细胞之间进行传递.肺泡上皮细胞通过分泌外泌体来调节机体固有免疫反应.在特定的刺激条件下,肺泡上皮细胞分泌的外泌体通过传递不同效应活性物质,靶向调节巨噬细胞极化通路中的基因表达,参与控制肺部炎症反应的巨噬细胞极化调节.本篇综述主要阐述肺泡上皮细胞源性外泌体,通过靶向调节巨噬细胞极化,调控急性肺损伤(acute lung injury,ALI)作用的最新研究进展,为相关研究提供参考.
Abstract
As messengers in the intercellular microenvironment,exosomes can mediate the transmission of signals between cells.Alveolar epithelial cells can regulate the body's innate immune response in the form of exosomes.Under specific stimulation conditions,exosomes derived from alveolar epithelial cells target and regulate the gene expression pathway by delivering different effector active substances,and participate in the regulation of macrophage polarization,thereby controlling the pulmonary inflammatory response.This article reviews the latest research progress of alveolar epithelial cell-derived exosomes in regulating acute lung injury(ALI)by targeting macrophage polarization,provide reference for related research.
关键词
脓毒症/急性肺损伤/肺泡上皮细胞/巨噬细胞/外泌体Key words
sepsis/acute lung injury/alveolar epithelial cells/alveolar macrophages/exosomes引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据