In the process of bone development,bones are formed by intramembranous osteogene-sis and endochondral osteogenesis,endochondral ossification is the second stage of long bone de-velopment,growth plate is the body for intrachondral ossification,growth plate chondrocytes damaged will destroy the process of intrachondral osteogenesis,seriously inhibit bone develop-ment or produce bone diseases.Exosomes are formed by the bilayer invagination of the mem-brane,and extracellular vesicles with lipid bilayers can envelop proteins,lipids,and nucleic acids(non-coding RNA,mRNA),etc.,acting on target cells to play a key role in intercellular com-munication.Exosomes have been the focus of research in recent years,and a large number of studies have found that they are closely related to bone development and the occurrence and treat-ment of bone diseases.Therefore,this article mainly reviews the effects of exosomes from differ-ent sources on bone development and bone diseases,and sorts out the regulatory effects of exo-somes from different sources on bone,so as to provide a theoretical basis for exploring the pre-vention and treatment of exosomes from different sources in the development of livestock and poultry bones and bone diseases.
关键词
外泌体/不同来源/骨骼疾病/骨骼发育
Key words
exosomes/different sources/bone diseases/bone development
维普
万方数据